114869-96-4Relevant academic research and scientific papers
Formal synthesis of a disaccharide repeating unit (IdoA-GlcN) of heparin and heparan sulfate
Sawant, Ratnnadeep C.,Liao, Ying-Ju,Lin, Yi-Jyun,Badsara, Satpal Singh,Luo, Shun-Yuan
, p. 19027 - 19033 (2015)
A concise route to access the key disaccharide repeating unit (IdoA-GlcN) of heparan sulfate is described. The synthesis was accomplished by commercially available diacetone α-d-glucose to functional group transformations, which led to the formation of a
SYNTHESIS OF HEPARIN FRAGMENTS: A METHYL α-PENTANOSIDE WITH HIGH AFFINITY FOR ANTITHROMBIN III
Petitou, Maurice,Duchaussoy, Philippe,Lederman, Isidore,Choay, Jean,Jaquinet, Jean-Claude,et al.
, p. 67 - 76 (2007/10/02)
The synthesis is described of the methyl α-glycoside of the pentasaccharide which represents the sequence in heparin responsible for binding and activation of the anticoagulant protein Antithrombin III.It was obtained in a yield much better than that of the previously synthesized pentasaccharide and exhibited the same biological properties.
