114878-60-3

Basic information

• Product Name: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE
• Synonyms: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE;BUTTPARK 83\09-66;(2-Chloro-4-nitrophenyl)piperazine;1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE >98%;3-Chloro-4-(piperazin-1-yl)nitrobenzene, 2-Chloro-4-nitro-1-(piperazin-1-yl)benzene;BAS 00805288;EU-0035959;MLS000689042
• CAS NO: 114878-60-3
• Molecular Formula: C₁₀H₁₂ClN₃O₂
• Molecular Weight: 241.67
• Product Categories: Amines and Anilines;Heterocycles;Piperaizine;API intermediates;piperazines
• Mol File: 114878-60-3.mol

Chemical Properties

• Melting Point: 105 °C
• Boiling Point: 411 °C at 760 mmHg
• Flash Point: 202.4 °C
• Appearance: /Solid
• Density: 1.331 g/cm³
• Vapor Pressure: 5.78E-07mmHg at 25°C
• Refractive Index: 1.589
• PKA: 8.53±0.10(Predicted)
• CAS DataBase Reference: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE(114878-60-3)
• EPA Substance Registry System: 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE(114878-60-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 114878-60-3(Hazardous Substances Data)

Usage

Uses

Used in Chemical and Pharmaceutical Industries:
1-(2-Chloro-4-nitrophenyl)-piperazine is used as a chemical intermediate for the synthesis of various pharmaceutical products, leveraging its biological activities and chemical properties. Its role in these industries is crucial for the development of new drugs and therapeutic agents.
Used in Research and Development:
CNPP serves as a valuable compound in research and development settings, where it can be studied for its potential applications and effects. Researchers may explore its interactions with biological systems, its role in chemical reactions, and its potential use in the creation of new compounds with therapeutic benefits.

InChI:InChI=1/C10H12ClN3O2/c11-9-7-8(14(15)16)1-2-10(9)13-5-3-12-4-6-13/h1-2,7,12H,3-6H2

Upstream product

• 123-91-1 1,4-dioxane 
• 110-85-0 piperazine 
• 99-54-7 3,4-dichloronitrobenzene 

Downstream Products

• 341001-38-5 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenylisoxazol-4-yl)methanone 
• 1370420-13-5 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(4-(2-methoxyphenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methanone 
• 312537-30-7 [4-(2-chloro-4-nitro-pheny1)-piperazin-1-yl]-[3-(2-chloro-phenyl)-5-methylisoxazol-4-yl]-methanone 
• 1370421-09-2 (4-(4-azido-2-chlorophenyl)piperazin-1-yl)(3-(2-chlorophenyl)-5-methylisoxazol-4-yl)methanone 
• 1370421-10-5 (4-(4-amino-2-chlorophenyl)piperazin-1-yl)(3-(2-chlorophenyl)-5-methylisoxazol-4-yl)methanone 
• 1362020-27-6 biphenyl-2-yl(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)-methanone 
• 1362020-25-4 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(3-methyl-5-phenylisoxazol-4-yl)methanone 
• 1362020-32-3 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(2'-methoxybiphenyl-2-yl)methanone 
• 1362020-47-0 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(4-ethyl-1-(2-methoxyphenyl)-1H-1,2,3-triazol-5-yl)methanone 
• 1362020-46-9 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(2-methoxyphenyl)-1H-1,2,3-triazol-5-yl)methanone 
• 1362020-45-8 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(2,6-dimethoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone 
• 1362020-44-7 1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone 
• 1362020-43-6 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(2-isopropoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone 
• 1362020-42-5 (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(2-ethoxyphenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone 

Relevant articles and documents

ANTIVIRAL COMPOUNDS AND METHODS OF MAKING AND USING THERE OF CROSS REFERENCE TO RELATED APPLICATIONS

Compounds which exhibit antiviral activity, particularly against influenza virus,and methods of making and using there of are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteralor parenteral administration. The compounds are preferably used to treat or prevent Influenza Ainfections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.

ANTIVIRAL COMPOUNDS AND METHODS OF MAKING AND USING THEREOF

Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.

Sulfanyl substituted phenyl methanones

The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.

4-Substituted-1-(4-alkylsulphonamidophenyl)piperazines as antiarrhythmic agents

Antiarrhythmic agents of the formula: STR1 and their pharmaceutically acceptable salts, wherein R and R1, which are the same or different, are C1 -C4 alkyl, C3 -C7 cycloalkyl, --CH2 CH

Studies in Potential Filaricides: Part XV - Synthesis of 1-Acyl/Aryl-4-substituted-piperazines as Diethylcarbamazine Analogs

1-Acyl-4-substituted-piperazines (4-29) have been prepared starting from 1-benzylpiperazine while 1-aryl-4-aroylpiperazines (30-44) have been obtained from the corresponding 1-arylpiperazines.None of the compounds shows any significant filaricidal activity against Litomosoides carinii in cotton rats and cestodicial activity against Hymenolepis nana in mice.