341001-38-5

Basic information

• Product Name: Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-
• Synonyms: Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-;[4-(2-Chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)methanone;Nucleozin;[4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone;1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine
• CAS NO: 341001-38-5
• Molecular Formula: C₂₁H₁₉ClN₄O₄
• Molecular Weight: 426.85
• Mol File: 341001-38-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 673.8 °C at 760 mmHg
• Flash Point: 361.3 °C
• Appearance: yellow/
• Density: 1.371
• Vapor Pressure: 5.17E-18mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: 2-8°C
• Solubility: DMSO: >15mg/mL
• CAS DataBase Reference: Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-(341001-38-5)
• EPA Substance Registry System: Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-(341001-38-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• Hazardous Substances Data: 341001-38-5(Hazardous Substances Data)

Usage

General Description

Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-, also known as isoxoprine, is a chemical compound with a complex molecular structure. It is a piperazine derivative that has been studied for its potential pharmacological properties, particularly in the field of neuroscience and cardiovascular medicine. Isoxoprine has been investigated for its vasodilatory and antiplatelet effects, and it has been used in the treatment of peripheral vascular diseases. Additionally, it has also been studied for its potential in improving blood flow in the brain and for its anti-inflammatory properties. Despite its potential therapeutic benefits, further research is needed to fully understand the pharmacological effects and safety profile of isoxoprine.

InChI:InChI=1/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3

Upstream product

• 100-52-7 benzaldehyde 
• 1136-45-4 5-methyl-3-phenylisoxazol-4-carboxylic acid 
• 114878-60-3 1-(2-chloro-4-nitro-phenyl)piperazine 
• 99-54-7 3,4-dichloronitrobenzene 
• 932-90-1 Benzaldoxime 
• 698-16-8 benzohydroximoyl chloride 
• 16883-16-2 5-methyl-3-phenylisoxazole-4-carbonyl chloride 

Relevant articles and documents

METHANETHIONE COMPOUNDS HAVING ANTIVIRAL ACTIVITY

A compound of formula (I), The compound is useful as an antiviral agent, in particular for the treatment of influenza. A method for preparing the compound of formula (I) and a composition comprising the compound of formula (I).

ANTIVIRAL COMPOUNDS AND METHODS OF MAKING AND USING THEREOF

Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.