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N-Debenzoyl-7-[(2,2,2,-trichloroethyl)oxy]carbonylpaclitaxel is a derivative of the well-known chemotherapeutic agent, paclitaxel (Taxol). It is a white solid with potent antitumor properties, making it a promising candidate for cancer treatment.

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  • 114915-15-0 Structure
  • Basic information

    1. Product Name: N-Debenzoyl-7-{[(2,2,2,-trichloroethyl)oxy]carbonyl}paclitaxel
    2. Synonyms: N-Debenzoyl-7-{[(2,2,2,-trichloroethyl)oxy]carbonyl}paclitaxel;N-Debenzoyl-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]taxol
    3. CAS NO:114915-15-0
    4. Molecular Formula: C43H48Cl3NO15
    5. Molecular Weight: 925.19792
    6. EINECS: N/A
    7. Product Categories: Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 114915-15-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: Ethyl Acetate, Methanol
    9. CAS DataBase Reference: N-Debenzoyl-7-{[(2,2,2,-trichloroethyl)oxy]carbonyl}paclitaxel(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-Debenzoyl-7-{[(2,2,2,-trichloroethyl)oxy]carbonyl}paclitaxel(114915-15-0)
    11. EPA Substance Registry System: N-Debenzoyl-7-{[(2,2,2,-trichloroethyl)oxy]carbonyl}paclitaxel(114915-15-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 114915-15-0(Hazardous Substances Data)

114915-15-0 Usage

Uses

Used in Pharmaceutical Industry:
N-Debenzoyl-7-[(2,2,2,-trichloroethyl)oxy]carbonylpaclitaxel is used as an antineoplastic agent for the treatment of various types of cancer. It functions by disrupting the normal function of microtubules within cancer cells, leading to cell cycle arrest and apoptosis.
Used in Anticancer Applications:
As an antineoplastic agent, N-Debenzoyl-7-[(2,2,2,-trichloroethyl)oxy]carbonylpaclitaxel is employed to combat different types of cancer, including breast, ovarian, lung, and pancreatic cancers. It exhibits significant cytotoxic effects on cancer cells, making it a valuable addition to the arsenal of cancer-fighting drugs.
Used in Drug Development:
N-Debenzoyl-7-[(2,2,2,-trichloroethyl)oxy]carbonylpaclitaxel is also used in the development of novel drug formulations and delivery systems. Its unique chemical properties allow for the creation of innovative therapies that can potentially improve the efficacy and safety of cancer treatments.
Used in Research and Development:
In the field of research, N-Debenzoyl-7-[(2,2,2,-trichloroethyl)oxy]carbonylpaclitaxel serves as an important compound for studying the mechanisms of action of paclitaxel and its derivatives. This knowledge can be applied to the development of new anticancer drugs and the optimization of existing treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 114915-15-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,9,1 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 114915-15:
(8*1)+(7*1)+(6*4)+(5*9)+(4*1)+(3*5)+(2*1)+(1*5)=110
110 % 10 = 0
So 114915-15-0 is a valid CAS Registry Number.

114915-15-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-Debenzoyl-7-{[(2,2,2,-trichloroethyl)oxy]carbonyl} Paclitaxel

1.2 Other means of identification

Product number -
Other names N-Debenzoyl-7-{[(2,2,2,-trichloroethyl)oxy]carbonyl} Paclitaxel

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114915-15-0 SDS

114915-15-0Relevant articles and documents

Design and synthesis of a taxoid library using radiofrequency encoded combinatorial chemistry

Xiao, Xiao-Yi,Parandoosh, Zahra,Nova, Michael P.

, p. 6029 - 6033 (2007/10/03)

Radiofrequency encoded combinatorial (REC) chemistry is a recently developed nonchemical encoding strategy in library synthesis. Encoded chemical libraries of complex molecular structures like Taxol can be constructed employing the noninvasive REC strategy and novel solid phase synthesis techniques, as demonstrated by the synthesis of the first 400- membered taxoid library in a discrete format and in quantities of multimilligrams/member.

Improved protection and esterification of a precursor of the taxotere and taxol side chains

Commercon,Bezard,Bernard,Bourzat

, p. 5185 - 5188 (2007/10/02)

(4S,5R)-N-BOC-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylic acid 8 was prepared and efficiently esterified by conveniently protected baccatins 9a,b. Smooth deprotection in formic acid gave the N-deprotected intermediates of Taxotere and taxol. This protocol did not generate any epimerization at C-2′ and constitutes a pratical method to prepare Taxotere, taxol and analogs.

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