- Using weak interactions to control C-H mono-nitration of indolines
-
An unprecedented C-H mononitration of indolines either at the -C5 or -C7 positions under mild condition is reported here. The roles of multiple weak interactions and factors such as steric factors, electronic effects, cation-π interactions, and solvent polarity were established, and we achieved a 100% regioselective electrophilic aromatic (EArS) nitration using Cu(NO3)2 or AgNO3.
- Bose, Anima,Mal, Prasenjit
-
supporting information
p. 11368 - 11371
(2017/10/19)
-
- DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS
-
The invention relates to diaminopyrroloquinazoline compounds of formula (I) wherein R1, Ra, Rb, Rc, Rd, Re, Rf and A are as defined in the specification and claims, which are useful for inhibiting protein tyrosine phosphatases, particularly PTP
- -
-
-
- The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones
-
The oxazolidinones are promising agents for the treatment of infections caused by gram-positive bacteria, including multidrug-resistant strains. In ongoing studies we have discovered that a strategically placed chiral center of appropriate absolute configuration improves the antibacterial activity of indolinyl oxazolidinone analogues (gram-positive MIC's0.5 μg/mL for the most potent congeners). The design, synthesis, antibacterial activity and pharmacokinetic profile of a selected series of α-methylated indoline derivatives and a related set of tetrahydroquinolyl and dihydrobenzoxazinyl analogues are discussed.
- Ciske, Fred L.,Barbachyn, Michael R.,Genin, Michael J.,Grega, Kevin C.,Lee, Chi Sing,Dolak, Lester A.,Seest, Eric P.,Watt, William,Adams, Wade J.,Friis, Janice M.,Ford, Charles W.,Zurenko, Gary E.
-
p. 4235 - 4239
(2007/10/03)
-
- Bicyclic oxazolidinones as antibacterial agents
-
The present invention provides compounds of formula I useful as antimicrobial agents wherein W, X, Y, R1, R2 and n are as defined in thereof.
- -
-
-
- Zn2+ montmorillonite catalyzed 3-aza-Cope rearrangement under microwave irradiation
-
N-Allylanilines undergo 3-aza-Cope rearrangement in the presence of Zn2+ montmorillonite under microwave irradiation in the absence of solvent to afford indoline derivatives in high yields. Similarly arylallyl thioethers are rearranged to dihydrobenzothiophenes.
- Yadav,Reddy, B.V. Subba,Rasheed, M. Abdul,Kumar, H. M. Sampath
-
p. 487 - 488
(2007/10/03)
-