- Electrochemical C-H Halogenations of Enaminones and Electron-Rich Arenes with Sodium Halide (NaX) as Halogen Source for the Synthesis of 3-Halochromones and Haloarenes
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Without employing an external oxidant, the simple synthesis of 3-halochromones and various halogenated electron-rich arenes has been realized with electrode oxidation by employing the simplest sodium halide (NaX, X = Cl, Br, I) as halogen source. This electrochemical method is advantageous for the simple and mild room temperature operation, environmental friendliness as well as broad substrate scope in both C-H bond donor and halogen source components.
- Jin, Jun,Lin, Yan,Liu, Yunyun,Wan, Jie-Ping,Wang, Chaoli
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p. 12378 - 12385
(2021/09/07)
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- Synthesis of 3-halochromones with simple KX halogen sources enabled by: In situ halide oxidation
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On the basis of a designated in situ oxidation tactic, the synthesis of 3-halochromones has been realized for the first time by using simple KX (X = Br, I) salts as halogen sources. Instead of the free radical process, the control experiments indicate that the reported reactions proceed through a halogenium intermediate. Compared to the known synthetic methods relying on molecular halogen, haloid acid or N-halosuccinimide as the halogen source, the present method is attractive due to its higher atom economy and being more friendly to the operator, thus providing a practical complimentary approach to the preparation of useful halochromone compounds.
- Lin, Yan,Liu, Yunyun,Wan, Jie-Ping
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p. 8120 - 8124
(2020/06/09)
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- Substituted 4H-1-Benzopyran-4-ones (Chromones): Synthesis via Palladium-catalysed Coupling of their Halogeno Derivatives with Alkenes
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Activation of bromochromones has been achieved by Pd0 insertion into the carbon-halogen bond.The resultant species undergo coupling with alkenes leading to vinylated chromones.Vinylation occurs regiospecifically at the original site of bromination and therefore provides a method for the clean introduction of substituents into the chromone ring system.An anomalous reaction of a dibrominated chromone leading to a ring-opened product is described.
- Davies, Stephen G.,Mobbs, Bryan E.,Goodwin, Christopher J.
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p. 2597 - 2604
(2007/10/02)
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