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CAS

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115913-83-2

1-(3-cyano-3-deoxy-beta-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 115913-83-2 Structure

  • Basic information

    1. Product Name: 1-(3-cyano-3-deoxy-beta-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
    2. Synonyms: 1-(3-Cyano-3-deoxy-.beta.-D-arabinofuranosyl)thymine; 1-(3-Cyano-3-deoxy-beta-D-arabinofuranosyl)thymine; 2,4(1H,3H)-Pyrimidinedione, 1-(3-cyano-3-deoxy-.beta.-D-arabinofuranosyl)-5-methyl-; 2,4(1H,3H)-Pyrimidinedione, 1-(3-cyano-3-deoxy-beta-D-arabinofuranosyl)-5-methyl-
    3. CAS NO:115913-83-2
    4. Molecular Formula: C11H13N3O5
    5. Molecular Weight: 267.238
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 115913-83-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.55g/cm3
    6. Refractive Index: 1.628
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(3-cyano-3-deoxy-beta-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(3-cyano-3-deoxy-beta-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(115913-83-2)
    11. EPA Substance Registry System: 1-(3-cyano-3-deoxy-beta-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione(115913-83-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 115913-83-2(Hazardous Substances Data)

115913-83-2 Usage

Chemical Class

Pyrimidine nucleosides

Explanation

The compound belongs to a class of chemical compounds known as pyrimidine nucleosides, which are derivatives of the base pyrimidine.

Explanation

It is used as an antiviral medication, particularly for the treatment of HIV and Hepatitis B.

Explanation

The compound works by inhibiting the reverse transcriptase enzyme, which is essential for the replication of the viruses.

Explanation

It has shown promising results in reducing the viral load in patients with HIV and Hepatitis B.

Explanation

The compound helps in slowing down the progression of HIV and Hepatitis B by inhibiting the replication of the viruses.

Explanation

The compound is still under investigation for potential use in other antiviral therapies.

Explanation

The compound has a specific chemical structure, which includes a 5-methylpyrimidine base attached to a modified sugar moiety (3-cyano-3-deoxy-beta-D-arabinofuranosyl).

Explanation

The compound is a synthetic nucleoside analog, meaning it is a modified version of a naturally occurring nucleoside with antiviral properties.

Application

Antiviral medication

Mechanism of Action

Inhibition of reverse transcriptase enzyme

Effect on Viral Load

Reduction

Impact on Disease Progression

Slowing down

Current Status

Under investigation

Structure

1-(3-cyano-3-deoxy-beta-D-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione

Synthetic Analog

Yes

Check Digit Verification of cas no

The CAS Registry Mumber 115913-83-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,9,1 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 115913-83:
(8*1)+(7*1)+(6*5)+(5*9)+(4*1)+(3*3)+(2*8)+(1*3)=122
122 % 10 = 2
So 115913-83-2 is a valid CAS Registry Number.

115913-83-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S,3S,4S,5R)-4-hydroxy-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolane-3-carbonitrile

1.2 Other means of identification

Product number -
Other names 3'-CN-araT

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115913-83-2 SDS

115913-83-2Downstream Products

115913-83-2Relevant articles and documents

SYNTHESIS AND ANTI-HIV ACTIVITY OF 3'-CYANO-2',3'-DIDEOXYTHYMIDINE AND 3'-CYANO-2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE

Matsuda, Akira,Satoh, Mutsumi,Nakashima, Hideki,Yamamoto, Naoki,Ueda, Tohru

, p. 2545 - 2548 (2007/10/02)

3'-Cyano-2',3'-dideoxy- and 3'-cyano-2',3'-didehydro-2',3'-dideoxythymidines (4,5) have been synthesized from 5-methyluridine (7).Anti-HIV activity of these compounds is also described.

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

Herdewijn,Balzarini,Baba,Pauwels,Van Aerschot,Janssen,De Clerq

, p. 2040 - 2048 (2007/10/02)

A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and pyrimidine 2',3'-dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged as the most potent and/or selective inhibitors of HIV-induced cytopathogenicity (in order of decreasing selectivity: 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2',3'-dideoxyuridine (AzddUrd), 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeCyd), 3'-fluoro-ddUrd (FddUrd), 3'-fluoro-ddThd (FddThd), the N4-hydroxylated derivative of AzddMeCyd and the N4-methylated derivative of AzddMeCyd. Among the purine 2',3'-dideoxynucleosides, 3'-azido-2',3'-dideoxyguanosine (AzddGuo), 3'-fluoro-ddGuo (FddGuo), and 3'-fluoro-2,6-diaminopurine 2',3'-dideoxynucleoside (FddDAPR) were the most selective inhibitors of HIV replication.

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