115941-56-5

Basic information

• Product Name: 1-(3-cyano-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine
• CAS NO: 115941-56-5
• Molecular Weight: 509.561
• Mol File: 115941-56-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-cyano-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-cyano-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine(115941-56-5)
• EPA Substance Registry System: 1-(3-cyano-3-deoxy-5-O-trityl-β-D-arabinofuranosyl)thymine(115941-56-5)

Safety Data

• Hazardous Substances Data: 115941-56-5(Hazardous Substances Data)

Upstream product

• 13435-20-6 tetraethylammoniumcyanide 
• 115913-84-3 1-(2,3-epoxy-5-O-trityl-β-D-lyxo-pentofuranosyl)thymine 

Downstream Products

• 115913-83-2 3'-cyano-3'-deoxy-β-D-arabinofuranosylthymine 
• 121336-21-8 1-(3'-cyano-2',3'-dideoxy-5'-O-trityl-β-D-threo-pentofuranosyl)thymine 
• 118222-08-5 1-(2',3'-dideoxy-3'-C-cyano-β-D-glyceropento-2'-enofuranosyl)thymine 
• 117174-38-6 1-(3'-C-cyano-2',3'-dideoxy-β-D-threo-pentofuranosyl)thymine 
• 116195-58-5 1-(3'-C-cyano-2',3'-dideoxy-β-D-erythro-pentofuranosyl)thymine 
• 118188-69-5 1-(3'-cyano-2',3'-dideoxy-5'-O-trityl-β-D-erythro-pentofuranosyl)thymine 
• 121336-20-7 (2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-2,5-dihydro-furan-3-carbonitrile 

Relevant articles and documents

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and pyrimidine 2',3'-dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged as the most potent and/or selective inhibitors of HIV-induced cytopathogenicity (in order of decreasing selectivity: 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2',3'-dideoxyuridine (AzddUrd), 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeCyd), 3'-fluoro-ddUrd (FddUrd), 3'-fluoro-ddThd (FddThd), the N4-hydroxylated derivative of AzddMeCyd and the N4-methylated derivative of AzddMeCyd. Among the purine 2',3'-dideoxynucleosides, 3'-azido-2',3'-dideoxyguanosine (AzddGuo), 3'-fluoro-ddGuo (FddGuo), and 3'-fluoro-2,6-diaminopurine 2',3'-dideoxynucleoside (FddDAPR) were the most selective inhibitors of HIV replication.