14486-22-7

Usage

Uses

Used in Pharmaceutical Industry:
2',3'-Anhydroadenosine is used as an intermediate in the synthesis of Cordycepin (C685800) for its potential therapeutic applications. Cordycepin, the first reported nucleoside antibiotic, has shown promise in various areas, including antiviral, antitumor, and immunomodulatory activities. The synthesis of Cordycepin involves the use of 2',3'-Anhydroadenosine, making it an essential component in the development of this pharmaceutical compound.

Upstream product

• 120649-60-7 2,2'-Anhydro-1-(3'-O-methylsulfonyl-β-D-arabinofuranosyl)thymine 
• 99631-18-2 2,2'-Anhydro-1-(5'-O-Benzoyl-3'-O-methylsulfonyl-β-D-arabinofuranosyl)thymine 
• 1463-10-1 5-Methyluridine 
• 120649-55-0 1-(5-O-benzoyl-β-D-ribofuranosyl)thymine 
• 120673-67-8 1-<5-O-Benzoyl-2,3-O-bis(methylsulfonyl)-β-D-ribofuranosyl>thymine 
• 3180-76-5 2',3',5'-tri-O-benzoyluridine 
• 138239-62-0 1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 
• 191538-87-1 C₁₉H₁₆O₅ 
• 65-71-4 thymin 
• 196867-32-0 1-(3',5'-di-O-benzoyl-2'-deoxy-2'-iodo-β-D-xylopentofuranosyl)thymine 
• 114551-08-5 5'-O-(4,4'-dimethoxytrityl)-1-(2,3-anhydro-β-D-lyxofuranosyl)thymine 

Downstream Products

• 115913-83-2 3'-cyano-3'-deoxy-β-D-arabinofuranosylthymine 

Relevant academic research and scientific papers

An efficient and highly stereoselective synthesis of nucleoside derivatives from furanoid 1,2-diols

Reaction between suitably protected furanoid glycals 1b-4b, readily obtained from furanoid 1,2-diols (1a-4a), and different silylated pyrimidine bases, gave the corresponding 3',5'- and 3',5',6'-O-protected 2'-deoxy-2'-iodo-β-D-xylo-pentofuranosyl 5-10 and β-D-gluco-hexofuranosyl 11 nucleosides, respectively. Compound 5 has been transformed into its 2'-deoxy 12 and 2',3'-anhydro 14 derivatives. The high stereoselectivity of the reaction is discussed.

1-(2,3-anhydro-β-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus

We report here that 1-(2,3-anhydro-β-D-lyxofuranosyl)cytosine has activity against the human immunodeficiency virus in vitro. A number of 2',3'-anhydro-β-D-lyxofuranosyl nucleoside derivatives were prepared, but none had the activity of the title compound. New efficient procedures were developed for the synthesis of 3'-deoxy-3'-alkyl- and 3'-deoxy-β-D-arabinosylpyrimidine derivatives.