115974-97-5

Basic information

• Product Name: Benzoic acid, 4-[(1E)-3-methoxy-3-oxo-1-propenyl]-
• CAS NO: 115974-97-5
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• Mol File: 115974-97-5.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(1E)-3-methoxy-3-oxo-1-propenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(1E)-3-methoxy-3-oxo-1-propenyl]-(115974-97-5)
• EPA Substance Registry System: Benzoic acid, 4-[(1E)-3-methoxy-3-oxo-1-propenyl]-(115974-97-5)

Safety Data

• Hazardous Substances Data: 115974-97-5(Hazardous Substances Data)

Upstream product

• 16695-14-0 Malonic acid monomethyl ester 
• 619-66-9 4-Carboxybenzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 619-58-9 4-iodobenzoic acid 
• 292638-85-8 acrylic acid methyl ester 
• 456-25-7 p-carboxyphenyl diazonium tetrafluoroborate 
• 38330-80-2 monomethyl monopotassium malonate 
• 5927-18-4 trimethyl phosphonoacetate 
• 110-89-4 piperidine 
• 7560-50-1 methyl (2E)-3-(4-formylphenyl)acrylate 
• 619-67-0 4-Hydrazinobenzoic acid 
• 623-27-8 terephthalaldehyde, 

Downstream Products

• 52148-89-7 methyl (E)-4-(3-methoxy-3-oxoprop-1-en-1-yl)benzoate 
• 117076-42-3 4-<2-(Methoxycarbonyl)ethenyl>benzoyl-chlorid 
• 189268-15-3 methyl (2E)-3-(4-{[(2-pyridinylmethyl)amino]carbonyl}phenyl)-2-propenoate 
• 179625-38-8 4-[2-(methoxycarbonyl)ethyl]benzoic acid 
• 141286-90-0 methyl (E)-3-(4-(hydroxymethyl)phenyl)acrylate 
• 683273-35-0 methyl (2E)-3-{4-[(4-pyridinylamino)carbonyl]phenyl}-2-propenoate 
• 1057107-39-7 C₁₂H₁₂O₄ 
• 653307-14-3 6-({4-[(1E)-3-methoxy-3-oxoprop-1-enyl]benzoyl}oxy)hexyl 2-(4-nitrobenzyl)-3-(4-nitrophenyl)propanoate 

Relevant articles and documents

Reduction of Electron-Deficient Alkenes Enabled by a Photoinduced Hydrogen Atom Transfer

Direct hydrogen atom transfer from a photoredox-generated Hantzsch ester radical cation to electron-deficient alkenes has enabled the development of an efficient formal hydrogenation under mild, operationally simple conditions. The HAT-driven mechanism is supported by experimental and computational studies. The reaction is applied to a variety of cinnamate derivatives and related structures, irrespective of the presence of electron-donating or electron-withdrawing substituents in the aromatic ring and with good functional group compatibility. (Figure presented.).

Palladium and phase transfer catalyzed heck cross coupling reaction in water under microwave irradiation

Palladium-catalyzed vinylation of aryl halides in water without organic cosolvent via microwave irradiation under phase transfer conditions gives the trans-stilbenes and substituted trans-cinnamic acid in good to high yield.

HISTONE DEACETYLASE 6 INHIBITORS AND METHOD FOR TREATING NEUROPATHIC PAIN

Disclosed herein are hydroxamic acid compounds. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6.

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors

In order to take advantage of both immunotherapeutic and epigenetic antitumor agents, the first generation of dual indoleamine 2,3-dioxygenase 1 (IDO1) and histone deacetylase (HDAC) inhibitors were designed. The highly active dual inhibitor 10 showed exc

HISTONE DEACETYLASE 6 INHIBITORS AND USE THEREOF

Disclosed is hydroxamic acid compounds of Formula (I) set forth herein. Also disclosed are a pharmaceutical composition containing such a compound and a method of using the compound for treating a condition associated with histone deacetylase 6.

Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors

Inhibition of histone deacetylase (HDAC) has been regarded as a potential therapeutic approach for treatment of multiple diseases including cancer. Based on pharmacophore model of HDAC inhibitors, a series of quinoline-based N-hydroxycinnamamides and N-hydroxybenzamides were designed and synthesized as potent HDAC inhibitors. All target compounds were evaluated for their in?vitro HDAC inhibitory activities and anti-proliferative activities and the best compound 4a surpass Vorinostat in both enzymatic inhibitory activity and cellular anti-proliferative activity. In terms of HDAC isoforms selectivity, compounds 4a exhibited preferable inhibition for class I HDACs, especially for HDAC8, the IC50 value (442?nM) was much lower than that of Vorinostat (7468?nM). Subsequently, we performed class I & IIa HDACs whole cell enzyme assay to evaluate inhibitory activity in whole cell context. Compounds 4a and 4e displayed much better cellular activity for class I HDACs than that for class IIa HDACs, which indicated that 4a and 4e might be potent class I HDAC inhibitors. Meanwhile, flow cytometry analysis showed that compound 4a and 4e can promote cell apoptosis in?vitro.

Synthesis of surface-active N-heterocyclic carbene ligand and its Pd-catalyzed aqueous Mizoroki–Heck reaction

A surface-active N-heterocyclic carbene (NHC) ligand with an octaethylene glycol monomethyl ether and n-dodecyl chain was synthesized. The NHC and its Pd complex behaved as a general surfactant, and hydrophobic oily substrates such as iodobenzene and styrene were emulsified in water, resulting in the acceleration of the Mizoroki–Heck reaction under heterogeneous conditions. Our results demonstrated that the reactive emulsion interface rendered by the surface-active NHC is effective for the aqueous Mizoroki–Heck reaction.

Oxidative cleavage of olefins by in situ-generated catalytic 3,4,5,6-tetramethyl-2-iodoxybenzoic acid/oxone

Oxidative cleavage of a variety of olefins to the corresponding ketones/carboxylic acids is shown to occur in a facile manner with 3,4,5,6-tetramethyl-2-iodobenzoic acid (TetMe-IA)/oxone. The simple methodology involves mere stirring of the olefin and catalytic amount (10 mol %) of TetMe-IA and oxone in acetonitrile-water mixture (1:1, v/v) at rt. The reaction mechanism involves initial dihydroxylation of the olefin with oxone, oxidative cleavage by the in situ-generated 3,4,5,6-tetramethyl-2-iodoxybenzoic acid (TetMe-IBX), and oxidation of the aldehyde functionality to the corresponding acid with oxone. Differences in the reactivities of electron-rich and electron-poor double bonds have been exploited to demonstrate chemoselective oxidative cleavage in substrates containing two double bonds.

Palladium-catalyzed C-C bond formation of arylhydrazines with olefins via carbon-nitrogen bond cleavage

The unactivated carbon-nitrogen bond of various aryl hydrazines was cleaved under very mild conditions by Pd(0) with the assistance of Pd(II). The in situ generated aryl palladium complex readily takes part in the C-C bond formation with olefins. This study offered a new mode of C-Pd bond formation, which will spur the development of palladium-catalyzed cross-coupling in the future.

6-Aminoisoquinoline Compounds

6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.