116008-37-8

Basic information

• Product Name: sodium pyridine-4-sulfinate
• Synonyms: sodium pyridine-4-sulfinate
• CAS NO: 116008-37-8
• Molecular Weight: 165.148
• Mol File: 116008-37-8.mol

Chemical Properties

• CAS DataBase Reference: sodium pyridine-4-sulfinate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium pyridine-4-sulfinate(116008-37-8)
• EPA Substance Registry System: sodium pyridine-4-sulfinate(116008-37-8)

Safety Data

• Hazardous Substances Data: 116008-37-8(Hazardous Substances Data)

Upstream product

• 4556-23-4 pyridine-4-thiol 
• 134479-04-2 pyridine-4-sulfonyl chloride 

Downstream Products

• 553-26-4 4,4'-bipyridine 
• 4423-10-3 4-(p-tolyl)pyridine 
• 5938-16-9 4-(4-methoxylphenyl)pyridine 
• 220000-88-4 4-(4-trifluoromethyl-phenyl)-pyridine 
• 861024-61-5 4-([1,1’-biphenyl]-4-yl)pyridine 
• 939-23-1 p-phenylpyridine 
• 39795-58-9 4-(4-fluorophenyl)pyridine 
• 39574-19-1 4-benzenesulfonyl-pyridine 
• 33399-48-3 4-(phenylthio)pyridine 

Relevant articles and documents

Mechanistic Studies of the Palladium-Catalyzed Desulfinative Cross-Coupling of Aryl Bromides and (Hetero)Aryl Sulfinate Salts

Pyridine and related heterocyclic sulfinates have recently emerged as effective nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with (hetero)aryl halides. These sulfinate reagents are straightforward to prepare, stable to storage and coupling reaction conditions, and deliver efficient reactions, thus offering many advantages, compared to the corresponding boron-derived reagents. Despite the success of these reactions, there are only scant details of the reaction mechanism. In this study, we use structural and kinetic analysis to investigate the mechanism of these important coupling reactions in detail. We compare a pyridine-2-sulfinate with a carbocyclic sulfinate and establish different catalyst resting states, and turnover limiting steps, for the two classes of reagent. For the carbocyclic sulfinate, the aryl bromide oxidative addition complex is the resting state intermediate, and transmetalation is turnover-limiting. In contrast, for the pyridine sulfinate, a chelated Pd(II) sulfinate complex formed post-transmetalation is the resting-state intermediate, and loss of SO2 from this complex is turnover-limiting. We also investigated the role of the basic additive potassium carbonate, the use of which is crucial for efficient reactions, and deduced a dual function in which carbonate is responsible for the removal of free sulfur dioxide from the reaction medium, and the potassium cation plays a role in accelerating transmetalation. In addition, we show that sulfinate homocoupling is responsible for converting Pd(OAc)2 to a catalytically active Pd(0) complex. Together, these studies shed light on the challenges that must be overcome to deliver improved, lower temperature versions of these synthetically important processes.

Preparation method of substituted sulfinate

The invention discloses a preparation method of substituted sulfinate, which comprises the following steps: by using substituted sulfonyl chloride as a raw material, carrying out hydrolysis reductionreaction on the substituted sulfonyl chloride in water in the presence of a reducing agent and an acid-binding agent to generate the corresponding substituted sulfinate. The method is a novel method which is easy to implement and suitable for industrial scale production and is used for preparing sulfinate and derivatives thereof. The method is simple in technological process, high in product purity and safe and environment-friendly, wherein the waste gas, solid and liquid are easy to treat.

Transition-Metal-Free Desulfinative Cross-Coupling of Heteroaryl Sulfinates with Grignard Reagents

A mild cross-coupling reaction of heteroaryl sulfinates with Grignard reagents has been developed under transition-metal-free conditions. This study provides an example of the SO22- as a leaving group in an aromatic system and an effective methodology for the construction of C-C bond.

An efficient heterogeneous copper fluorapatite (CuFAP)-catalysed oxidative synthesis of diaryl sulfone under mild ligand- and base-free conditions

A simple, eco-friendly and efficient method for the synthesis of unsymmetrical diaryl sulfones using heterogeneous copper fluorapatite (CuFAP)-catalysed coupling of aryl sulfonic acid and phenyl boronic acid has been developed with good to excellent yields without use of any ligand, base or co-catalyst. Broad substrate scope and gram scale operations are the important features of this method.

A Novel Synthesis of Aromatic Sulfinic Acids

Aromatic sulfinic acids were synthesized conveniently by the direct oxidation of thiols with 30percent aqueous hydrogen peroxide at room temperature in good yield.Keywords - oxidation; thiol; sulfinic acid; benzene sulfinic acid; hydrogen peroxide.