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Usage

Uses

Used in Organic Chemistry Research:
4-(4-BIPHENYL)PYRIDINE is used as a building block for synthesizing various functional materials, contributing to its importance as an intermediate in organic chemistry.
Used in Liquid Crystals Industry:
4-(4-BIPHENYL)PYRIDINE is used as a component in the development of liquid crystals, due to its unique electronic and optical properties that enhance the performance of these materials.
Used in Photovoltaic Materials Industry:
4-(4-BIPHENYL)PYRIDINE is used as a key intermediate in the synthesis of photovoltaic materials, playing a crucial role in the advancement of solar energy technologies.
Used in Organic Light-Emitting Diodes (OLEDs) Industry:
4-(4-BIPHENYL)PYRIDINE is used as a vital component in the production of OLEDs, where its electronic and optical properties are harnessed to improve the efficiency and performance of these devices.

Upstream product

• 55-22-1 pyridine-4-carboxylic acid 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 1591-31-7 4-iodo-biphenyl 
• 113964-72-0 triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate 
• 1120-87-2 4-bromopyridin 
• 5122-94-1 4-biphenylboronic acid 
• 15854-87-2 4-iodopyridine 
• 19524-06-2 4-bromopyridine hydrochloride 
• 116008-37-8 sodium pyridine-4-sulfinate 
• 110-86-1 pyridine 
• 13296-04-3 4-(pyridin-4-yl)aniline 
• 1692-15-5 4-pyridylboronic acid 
• 59656-60-9 N-(4-(pyridin-4-yl)phenyl)acetamide 

Downstream Products

• 5623-42-7 4-(4-biphenylyl)benzophenone 

Relevant academic research and scientific papers

Ternary Cocrystals with Large Soft Cavities: A 1,4-diiodotetrafluorobenzene (DITFB)?4-Biphenylpyridine N-oxide (BPNO) Host Assembled by Inclusion of Planar Aromatic Guests

A large soft-cavity host composed of 1,4-diiodotetrafluorobenzene (DITFB) and 4-biphenylpyridine N-oxide (BPNO) is assembled under the mediation of a planar aromatic guest molecule (pyrene or perylene) through C?I????O?N+ halogen bonds and π-hole???π bonds. Single-crystal X-ray diffraction reveals that guest molecules can be completely encapsulated in the four-layer host cavity to assemble ternary host-guest cocrystals; namely, Pyr@DITFB ? BPNO and Per@DITFB ? BPNO. The luminescence of these ternary cocrystals originates from their discrete guest molecules, which exhibit pure-blue and yellow emissions, respectively, that are localized at 425 nm and in the range of 485 to 578 nm, respectively. In addition, the contribution of different fragments to the stabilization of the crystal structure is estimated by computational chemistry. These cocrystals have significant potential for use in optical applications or materials, such as photonics or organic light-emitting diodes, respectively, that require to avoid the aggregation between luminophores.

Aggregation-induced phosphorescence emission (AIPE) behaviors in PtII(C^N)(N-donor ligand)Cl-type complexes through restrainedD2ddeformation of the coordinating skeleton and their optoelectronic properties

A series of four-coordinated PtII(C^N)(N-donor ligand)Cl-type complexes have been synthesized through combination between C^N-type and N-donor ligands with different sizes. Photophysical features, electrochemical behaviors and electroluminescent (EL) performances have been investigated in detail. Critically, the relationship between the size of organic ligands and aggregation-induced phosphorescence emission (AIPE) behaviors for these PtII(C^N)(N-donor ligand)Cl-type complexes has been characterized. With extending the dimensions of the C^N-type and/or N-donor ligands, the AIPE of these PtII(C^N)(N-donor ligand)Cl-type complexes is more likely to show up with lower H2O volumetric fractions (fw) in the THF solution of these complexes. These unique AIPE experimental results have clearly revealed a new AIE mechanism called restrainedD2ddeformation of the coordinating skeleton of these PtII(C^N)(N-donor ligand)Cl-type complexes from square-planar (D4h) in the ground states to the tetrahedron (Td) skeleton in the excited states. In addition, solution-processed organic light-emitting diodes (OLEDs) based on these AIPE emitters have been fabricated to characterize their EL potential. Impressive EL efficiencies with the maximum external quantum efficiency (ηext) of 25.2%, current efficiency (ηL) of 53.9 cd A?1and power efficiency (ηP) of 43.5 lm W?1can be achieved, indicating great potential of these PtII(C^N)(N-donor ligand)Cl-type AIPE emitters in the field of OLEDs. Importantly, this research has proposed a new AIE mechanism to promote the development of new phosphorescent AIPE complexes with great potential in the field of OLEDs.

Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts

Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki-Miyaura reaction

The Suzuki-Miyaura reaction is one of the most used transformations in drug research. Thus making this reaction more sustainable is of considerable current interest. Here we show that propylene carbonate (PC) can be used as a solvent for the Suzuki-Miyaura reaction. PC is one of the greenest solvents since it is synthesized under green conditions by the use of carbon dioxide in the air. All reactions proceeded well and good or excellent yields were observed for the biaryl products. Nonetheless in the case of pyridazinones, 2-hydroxypropyl- chain containing side-products were observed. Importantly, this fact allowed the isolation of several novel compounds which were generated under prominently green conditions.

Connecting a carbonyl and a π-conjugated group through a: P-phenylene linker by (5+1) benzene ring formation

A benzene ring was formed to connect a carbonyl group of various methyl ketones with a π-conjugated group through a p-phenylene linker. Methyl ketones and streptocyanines were used as the C1 and C5 sources, respectively, in the (5+1) annulation, which could form donor-π-acceptor molecules.

Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides

Pyridine rings are ubiquitous in drug molecules; however, the pre-eminent reaction used to form carbon-carbon bonds in the pharmaceutical industry, the Suzuki-Miyaura cross-coupling reaction, often fails when applied to these structures. This phenomenon is most pronounced in 2-substituted pyridines, and results from the difficulty in preparing, the poor stability of, and low efficiency in reactions of pyridine-2-boronates. We demonstrate that by replacing these boronates with pyridine-2-sulfinates, a cross-coupling process of unrivalled scope and utility is realized. The corresponding 3-And 4-substituted pyridine variants are also efficient coupling partners. In addition, we apply these sulfinates in a library format to the preparation of medicinally relevant derivatives of the drugs varenicline (Chantix) and mepyramine (Anthisan).

Palladium dichloride adduct of N,N-bis-(diphenylphosphanylmethyl)-2- aminopyridine: Synthesis, structure and catalytic performance in the decarboxylative cross-coupling of 4-picolinic acid with aryl bromide

Reaction of PdCl2 with N,N-bis-(diphenylphosphanylmethyl)-2- aminopyridine (bdppmapy) afforded a mononuclear complex [(bdppmapy)PdCl 2] (1). Compound 1 was characterized by elemental analysis, IR, 1H, 13C and 31P NMR, electrospray ion mass spectra (ESI-MS) and X-ray single crystal crystallography. The Pd(ii) center in 1 is chelated by bdppmapy, showing a cis-square planar geometry. With the assistance of additive Cu2O, complex 1 exhibited good catalytic activity toward the decarboxylative cross-coupling reactions between 4-picolinic acid and aryl bromides. In the presence of only 2 mol% catalyst, a family of 4-aryl-pyridines could be isolated in up to 83% yield.

Cp2Ni-KOt-Bu-BEt3 (or PPh3) catalyst system for direct C - H arylation of benzene, naphthalene, and pyridine

Ni-catalyzed direct C - H arylation of benzene and naphthalene using aryl halides was investigated. For the first time, the arylation was successfully catalyzed by Cp2Ni (5 mol %) in the presence of KOt-Bu and BEt 3. This Ni catalyst system was also applied to direct C - H arylation of pyridine, an electron-deficient heteroarene; PPh3 was used instead of BEt3 in this case.

Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations

This article describes the design, optimisation and development of a Suzuki cross-coupling protocol mediated by an efficient palladium-en-capsulated catalyst (Pd EnCat) under microwave irradiation. The methodology has been used in both batch mode for classical library preparation and in continuous-flow applications furnishing multigram quantities of material. Described is a method that uses direct focused microwave heating whilst applying an external cooling source. This enables a lower than normal bulk temperature to be maintained throughout the reaction period leading to significant improvements in the overall yield and purity of the reaction products. Additional aspects of this novel heating protocol are discussed in relation to the prolonged lifetime and enhanced reactivity of the immobilised catalyst system.