117174-70-6

Basic information

• Product Name: 4-Methoxy-2,5-diMethylaniline
• Synonyms: 4-Methoxy-2,5-diMethylaniline;2,5-dimethyl-4-methoxyaniline
• CAS NO: 117174-70-6
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 117174-70-6.mol

Chemical Properties

• Boiling Point: 258.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.019±0.06 g/cm3(Predicted)
• PKA: 5.18±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxy-2,5-diMethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-2,5-diMethylaniline(117174-70-6)
• EPA Substance Registry System: 4-Methoxy-2,5-diMethylaniline(117174-70-6)

Safety Data

• Hazardous Substances Data: 117174-70-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 3096-64-8 N-(2,5-dimethylphenyl)hydroxylamine 
• 89-58-7 mononitro-p-xylene 
• 58106-25-5 1-bromo-4-methoxy-2,5-dimethylbenzene 

Downstream Products

• 4962-28-1 2,5-dimethyl-4-methoxyphenol 
• 706822-63-1 4-ethoxy-2,5-dimethyl-aniline 
• 1408250-53-2 C₂₀H₂₅ClFN₃O₃ 
• 1173523-81-3 (R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-hydroxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one 
• 1408250-51-0 18F-(R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one 
• 1408250-52-1 C₁₉H₂₃ClFN₃O₃ 
• 1408250-59-8 C₁₈H₂₄BrN₃O₄ 
• 1428768-45-9 C₂₀H₂₅ClFN₃O₃ 
• 1428768-65-3 C₂₅H₂₈ClN₃O₃ 
• 1428768-69-7 C₂₅H₂₈BrN₃O₃ 
• 327615-34-9 1-acetyl-4,7-dimethyl-5-[[2-methyl-3-(4-methylphenyl)-2-propenyl]oxy]-1,2-dihydro-1H-indole 
• 1173523-48-2 (R)-5-chloro-3-(4-methoxy-2,5-dimethylphenylamino)-1-(2-methoxy-1-methylethyl)pyrazin-2(1H)-one 
• 1173523-41-5 (R)-5-chloro-1-(1-cyclopropylpropyl)-3-(4-methoxy-2,5-dimethylphenylamino)pyrazin-2(1H)-one 
• 1173523-38-0 5-chloro-3-(4-methoxy-2,5-dimethylphenylamino)-1-(1-propylbutyl)pyrazin-2(1H)-one 

Relevant articles and documents

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds

Arylmetals are highly valuable carbon nucleophiles that are readily and inexpensively prepared from aryl halides or arenes and widely used on both laboratory and industrial scales to react directly with a wide range of electrophiles. Although C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absence of suitable heteroatom-transfer reagents. Here, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily available terpenoid scaffolds as efficient multifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroarylmetals. This practical and scalable method provides one-step synthetic access to primary anilines and phenols at low temperature and avoids the use of transition-metal catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup conditions.

TRICYCLIC DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS

A compound represented by the formula: wherein Ring A is a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, Ring B is benzene ring which is further substituted, Ring C is a dihydrofuran ring which may b