- Method for synthesizing zilpaterol hydrochloride
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The invention provides a method for synthesizing zilpaterol hydrochloride. The method comprises the following steps: (1) hydrogenating a compound (h) under the action of a nickel-based catalyst to obtain 6-aminobenzimidazolidone azepine-7-one (compound k); (2) carrying out an alkylation reaction on the 6-aminobenzimidazolidinone azepine-7-one and 2-bromopropane to obtain 6-isopropylaminobenzimidazolidoneazepine-7-one (compound m); and (3) reducing the 6-isopropylaminobenzimidazolidinoneazepine-7-one to obtain zilpaterol. The method has the advantages of no high pressure conditions, low cost, simplicity in operation, and suitableness for industrial large-scale production.
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Paragraph 0043; 0054-0057
(2018/11/22)
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- Zilpaterol Enantiomer Compositions and Methods of Making and Using Such Compositions
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This invention is directed generally to zilpaterol enantiomer compositions and, in particular, to compositions comprising the 6R,7R zilpaterol enantiomer. This invention is also directed to processes for making such compositions; methods for using such compositions to, for example, increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and/or fish; and uses of such compositions to make medicaments. This invention is further directed to methods for determining the absolute configurations of zilpaterol enantiomers.
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Page/Page column 7
(2010/02/17)
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- Synthesis and pharmacological characterization of β2- adrenergic agonist enantiomers: Zilpaterol
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The β-adrenergic agonist 1 (zilpaterol) is used as production enhancer in cattle. Binding experiments of separated enantiomers on recombinant human β2-adrenergic and μ-opioid receptors and functional studies showed that the (-)-1 enantiomer acc
- Kern, Christopher,Meyer, Thorsten,Droux, Serge,Schollmeyer, Dieter,Miculka, Christian
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experimental part
p. 1773 - 1777
(2010/01/16)
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- PROCESSES FOR MAKING ZILPATEROL AND SALTS THEREOF
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This invention generally relates to processes for making zilpaterol and salts thereof, as well as processes for making intermediates that, inter alia, may be used to make zilpaterol and salts thereof. The zilpaterol and salts prepared in accordance with this invention can be used to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.
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Page/Page column 31; 44
(2008/12/04)
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