119520-06-8

Usage

Uses

Used in Cattle Feeding Industry:
Zilpaterol hydrochloride is used as a feed additive to increase the rate of body weight gain in cattle fed in confinement systems before slaughter. It is particularly effective in improving feed efficiency and increasing carcass leanness, which results in a higher yield of gross primal and boneless closely trimmed primals, as well as boneless closely trimmed retail cuts as a percentage of carcass weight when carcass weights are held constant.
Additionally,

Solubility in organics

Zilpaterol hydrochloride is very soluble in water and in other aqueous media (about 50% of product dissolved) at different pH values (1–10). It is only slightly soluble in methanol (about 3%) and practically insoluble in most organic solvents (<0.1%) such as ethanol, acetone, ethyl-acetate, isopropyl ether, hexane, toluene, chloroform, dichloromethane or n-octanol.

InChI:InChI=1/C14H19N3O2.ClH/c1-8(2)15-11-6-7-17-12-9(13(11)18)4-3-5-10(12)16-14(17)19;/h3-5,8,11,13,15,18H,6-7H2,1-2H3,(H,16,19);1H/t11-,13-;/m1./s1

Upstream product

• 1021987-10-9 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one 
• 67-64-1 acetone 
• 3273-68-5 4-(1,2-dihydro-2-oxobenzo[d]imidazole-3-yl)butanoic acid 
• 1021910-67-7 chloro 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate 
• 92260-82-7 4,5,6,7-tetrahydro-6-hydroxyimino-imidazo[4,5,1-jk]-[1]-benzazepine-2,7(1H,6H)-dione 
• 92260-81-6 5,6-dihydroimidazo[4,5,1-jk][1]benzazepin-2,7-[1H,4H]-dione 
• 1001395-75-0 (6S,7S)-4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]imidazo[4,5,1-jk][1]benzazepin-2(1H)-one 
• 1019837-22-9 (6R,7R)-6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one 

Relevant academic research and scientific papers

A method for synthesizing uneven handkerchief Trow hydrochloric acid

An embodiment of the invention provides a method for synthesizing zilpaterol Hydrochloride, belonging to a medical synthesizing technology field. The method comprises: resolving 4,5,6,7-tetrahydro-6- hydroximino-imidazo[4,5,1-jk]-[1] benzoaza-2,7(1H,6H)-dione into a mixed solvent of methanol and DMF, adding the mixed solvent and a first catalyst together into a reactor, displacing air in the reactor through nitrogen and hydrogen, filling hydrogen into the reactor, stirring and raising temperature until the temperature is 30-50 DEG C and hydrogen pressure is 1-10 MPa, reacting for 4-24h, filtrating and recovering the catalyst after the reaction; and processing the filtrate through enamine forming, hydrogenation reduction, salt forming, crystallization and hydrochloride forming to obtain the zilpaterol Hydrochloride. The synthetic method of the zilpaterol Hydrochloride utilizes methanol and DMF as reaction solvents to raise a reaction rate, and the method provided by the invention can reduce hydrogenation reaction time below 12h.

PROCESS FOR MAKING A CRYSTALLINE ZILPATEROL SALT

This invention generally relates to processes for making a crystalline zilpaterol salt, particularly zilpaterol hydrochloride. This invention also relates to methods of treatment using a crystalline zilpaterol salt prepared in accordance with this invention to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.

PROCESS FOR MAKING A CRYSTALLINE ZILPATEROL SALT

This invention generally relates to processes for making a crystalline zilpaterol salt, particularly zilpaterol hydrochloride. This invention also relates to methods of treatment using a crystalline zilpaterol salt prepared in accordance with this invention to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.

Zilpaterol Enantiomer Compositions and Methods of Making and Using Such Compositions

This invention is directed generally to zilpaterol enantiomer compositions and, in particular, to compositions comprising the 6R,7R zilpaterol enantiomer. This invention is also directed to processes for making such compositions; methods for using such compositions to, for example, increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and/or fish; and uses of such compositions to make medicaments. This invention is further directed to methods for determining the absolute configurations of zilpaterol enantiomers.

Synthesis and pharmacological characterization of β2- adrenergic agonist enantiomers: Zilpaterol

The β-adrenergic agonist 1 (zilpaterol) is used as production enhancer in cattle. Binding experiments of separated enantiomers on recombinant human β2-adrenergic and μ-opioid receptors and functional studies showed that the (-)-1 enantiomer acc

ENANTIOSELECTIVE SYNTHESIS OF 6-AMINO-7-HYDROXY-4, 5, 6, 7-TETRAHYDRO-IMIDAZO [4, 5, 1-JK] [1] -BENZAZEPIN-2 [1H] -ONE AND ZILPATEROL

This invention relates to a process for the hydrogenation of a ketooxime to selectively form an aminoalcohol stereoisomer, and, in particular, to a process for the hydrogenation of 4,5-dihydro-imidazo[4,5,l-jk][1]benzazepin-2,6,7[1H]-trione-6-oxime or a salt thereof to selectively form a stereoisomer of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin-2[1H]-one or a salt thereof. This invention also relates to the use of the 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo[4,5,1-jk][1]-benzazepin- 2[1H]-one hydrogenation product or a salt thereof to selectively make a stereoisomer of zilpaterolor a salt thereof, as well as the use of such a zilpaterol stereoisomer or salt in methods of treatment and medicaments for animals.