Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy
Protein tyrosine phosphatases (PTPs) regulate a broad range of cellular processes including proliferation, differentiation, migration, apoptosis, and immune responses. Dysfunction of PTP activity is associated with cancers, metabolic syndromes, and autoim
Zhang, Sheng,Chen, Lan,Luo, Yong,Gunawan, Andrea,Lawrence, David S.,Zhang, Zhong-Yin
Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Al
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Paragraph 0059; 0060; 0082; 0083
(2016/01/09)
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