Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy

DOI: 10.1021/ja903733z

Source and publish data:

Journal of the American Chemical Society p. 13072 - 13079 (2009)

Update date:2022-08-05

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Authors:

Zhang, Sheng

Chen, Lan

Luo, Yong

Gunawan, Andrea

Lawrence, David S.

Zhang, Zhong-Yin

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Article abstract of DOI:10.1021/ja903733z

Protein tyrosine phosphatases (PTPs) regulate a broad range of cellular processes including proliferation, differentiation, migration, apoptosis, and immune responses. Dysfunction of PTP activity is associated with cancers, metabolic syndromes, and autoim

Full text of DOI:10.1021/ja903733z

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