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6-Chloroquinoline-3-carboxylic acid is a chlorinated derivative of quinoline, a heterocyclic aromatic compound with the molecular formula C10H6ClNO2. It is a yellow crystalline solid that is sparingly soluble in water and soluble in organic solvents. This chemical compound is primarily used in the synthesis of pharmaceuticals and agrochemicals, particularly for the production of antimalarial drugs and insecticides. It also serves as an intermediate in the manufacturing of various other organic compounds.

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  • 118791-14-3 Structure
  • Basic information

    1. Product Name: 6-chloroquinoline-3-carboxylic acid
    2. Synonyms: 6-chloroquinoline-3-carboxylic acid;3-Carboxy-6-chloroquinoline;6-Chloro-3-quinolinecarboxylic acid
    3. CAS NO:118791-14-3
    4. Molecular Formula: C10H6ClNO2
    5. Molecular Weight: 207.62
    6. EINECS: N/A
    7. Product Categories: CHIRAL CHEMICALS
    8. Mol File: 118791-14-3.mol
  • Chemical Properties

    1. Melting Point: 228 °C(Solv: ethanol (64-17-5))
    2. Boiling Point: 382.122 °C at 760 mmHg
    3. Flash Point: 184.901 °C
    4. Appearance: /
    5. Density: 1.47 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.69
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 2.02±0.30(Predicted)
    11. CAS DataBase Reference: 6-chloroquinoline-3-carboxylic acid(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-chloroquinoline-3-carboxylic acid(118791-14-3)
    13. EPA Substance Registry System: 6-chloroquinoline-3-carboxylic acid(118791-14-3)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 118791-14-3(Hazardous Substances Data)

118791-14-3 Usage

Uses

Used in Pharmaceutical Industry:
6-Chloroquinoline-3-carboxylic acid is used as a key intermediate in the synthesis of antimalarial drugs. Its unique chemical structure contributes to the development of effective treatments against malaria, a disease affecting millions of people worldwide.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Chloroquinoline-3-carboxylic acid is utilized as a precursor for the production of insecticides. Its incorporation into these products helps control and eliminate pests, thereby protecting crops and ensuring food security.
Used in Organic Synthesis:
6-Chloroquinoline-3-carboxylic acid is employed as an intermediate in the manufacturing of various organic compounds. Its versatile chemical properties allow it to be a valuable building block for the synthesis of a wide range of molecules with diverse applications.
It is important to handle 6-Chloroquinoline-3-carboxylic acid with care due to its potential health hazards and environmental impact. Proper safety measures should be taken during its production, use, and disposal to minimize any adverse effects.

Check Digit Verification of cas no

The CAS Registry Mumber 118791-14-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,7,9 and 1 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 118791-14:
(8*1)+(7*1)+(6*8)+(5*7)+(4*9)+(3*1)+(2*1)+(1*4)=143
143 % 10 = 3
So 118791-14-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H6ClNO2/c11-8-1-2-9-6(4-8)3-7(5-12-9)10(13)14/h1-5H,(H,13,14)

118791-14-3 Well-known Company Product Price

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  • Aldrich

  • (BBO000207)  6-Chloroquinoline-3-carboxylic acid  AldrichCPR

  • 118791-14-3

  • BBO000207-1G

  • 2,575.17CNY

  • Detail

118791-14-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Chloroquinoline-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names 6-chloroquinoline-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118791-14-3 SDS

118791-14-3Relevant articles and documents

Chemical compounds

-

, (2008/06/13)

Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.

Syntheses and Reactions of Diazepinoquinolines

Guendel, Wolf-H.,Bohnert, Sabine

, p. 769 - 777 (2007/10/02)

Three routes for the preparation of diazepinoquinolines (1) have been studied.The best yields resulted by starting from the amides of N-(3-quinolylcarbonyl)-N-alkyl-amino acids (5).Quaternization to 9, intramolecular cyclization under the influence of base to 10, oxidation to 11 and debenzylation by catalytic hydrogenation gave 1. - Keywords: Quinolinium Salts, Cyclization Reaction

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