375854-57-2

Usage

Uses

6-Chloro-quinoline-3-carboxylic acid ethyl ester

Upstream product

• 1001-26-9 ethyl 3-ethoxyacrylate 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 10601-80-6 ethyl 3,3-diethoxypropanoate 
• 873-76-7 para-Chlorobenzyl alcohol 
• 622-95-7 4-chlorobenzyl bromide 
• 27032-10-6 4-chlorobenzyl azide 

Downstream Products

• 118791-14-3 6-Chlor-3-chinolincarbonsaeure 

Relevant academic research and scientific papers

Visible light catalyzed synthesis of quinolines from (aza)-Morita-Baylis-Hillman adducts

A mild and efficient protocol for the synthesis of quinoline scaffolds from (aza)-MBH adducts under visible light catalysis has been established. The reaction involves visible light catalyzed generation of amidyl radicals from (aza)-MBH adducts followed by intramolecular radical cyclization. The reaction exhibits a wide substrate scope, good functional group tolerance and high regioselectivity. This is the first example of utilizing (aza)-MBH adducts for the generation of amidyl radicals and synthesizing aza-heterocycles under visible light photoredox catalyzed reaction conditions.

Synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters from arylmethyl azides via a domino process

A convenient synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters via a domino process is described. The synthesis employs arylmethyl azides as the precursor which undergoes an acid-promoted rearrangement to give an N-aryl iminium ion. Following the addition with ethyl 3-ethoxyacrylate, intramolecular electrophilic aromatic substitution, elimination and subsequent oxidation, the quinoline products were obtained in moderate to excellent yields.

A one-step synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid esters from o -nitrobenzaldehydes

A straightforward and efficient one-step procedure for the synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters is described. The simple reductive cyclization is carried out by treating various substituted o-nitrobenzaldehydes with inex

Chemical compounds

Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a condition, disease, or disorder that can be ameliorated by the administration of an inhibitor of tryptase, e.g., asthma and inflammatory diseases, to name only a few.