118971-00-9

Basic information

• Product Name: (S)-2-(1-METHOXY-1-METHYLETHYL)PYRROLIDINE
• Synonyms: (S)-2-(1-METHOXY-1-METHYLETHYL)PYRROLIDINE;(S)-2-(2-Methoxypropan-2-yl)pyrrolidine
• CAS NO: 118971-00-9
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.228
• Mol File: 118971-00-9.mol

Chemical Properties

• Boiling Point: 173℃
• Flash Point: 65℃
• Appearance: /
• Density: 0.910
• Vapor Pressure: 1.26mmHg at 25°C
• Refractive Index: 1.443
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.85±0.10(Predicted)
• CAS DataBase Reference: (S)-2-(1-METHOXY-1-METHYLETHYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(1-METHOXY-1-METHYLETHYL)PYRROLIDINE(118971-00-9)
• EPA Substance Registry System: (S)-2-(1-METHOXY-1-METHYLETHYL)PYRROLIDINE(118971-00-9)

Safety Data

• Hazardous Substances Data: 118971-00-9(Hazardous Substances Data)

Usage

Uses

Since the provided materials do not specify the uses of (S)-2-(1-METHOXY-1-METHYLETHYL)PYRROLIDINE, it is not possible to list its applications based on the given information. However, given its classification as a pyrrolidine and its presence in pharmaceuticals and agrochemicals, it can be inferred that this compound may have potential applications in these industries. To provide accurate use cases, more explicit information or data would be required.

InChI:InChI=1/C8H17NO/c1-8(2,10-3)7-5-4-6-9-7/h7,9H,4-6H2,1-3H3/t7-/m0/s1

Upstream product

• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 
• 129149-57-1 (S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine 
• 92053-25-3 (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine 
• 118970-92-6 (S)-(-)-1-benzyl-2-(1-hydroxy-1-methylethyl)-pyrrolidine 
• 121224-35-9 (S)-(-)-1-amino-2-(1'-methoxy-1'-methylethyl)pyrrolidine 
• 156358-43-9 (2S,3R)-1-[(S)-2-(1-Methoxy-1-methyl-ethyl)-pyrrolidin-1-yl]-5-methyl-1,2,3,4-tetrahydro-pyridine-2,3-dicarboxylic acid dimethyl ester 
• 118970-96-0 (S)-(-)-1-benzyl-2-(1-methoxy-1-methylethyl)-pyrrolidine 
• 129173-93-9 (S)-N-formyl-2-(1-methoxy-1-methylethyl)pyrrolidine 
• 51207-68-2 (2S)-N-Benzyloxycarbony-2-(1'-hydroxy-1'-methylethyl)pyrrolidine 

Downstream Products

• 137720-44-6 (S)-N-<2-(hydroxymethyl)benzoyl>-2-(1-methoxy-1-methylethyl)pyrrolidine 
• 137720-48-0 (S)-2-(1-methoxy-1-methylethyl)-1-(2-formylbenzoyl)pyrrolidine 
• 484689-81-8 1-[(S)-2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl]-2-methyl-3-phenylpropan-1-thione 
• 171234-88-1 N-<(S)-1-Benzyl-1-methyl-2-<(S)-2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>-2-thioxoethyl>benzamid 
• 171080-60-7 N-<(R)-1-Benzyl-1-methyl-2-<(S)-2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>-2-thioxoethyl>benzamid 
• 171080-59-4 (S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin 
• 171234-87-0 (S)-1-<(S)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin 
• 484689-80-7 (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on 
• 137720-43-5 (S)-N-(2-carbomethoxybenzoyl)-2-(1-methoxy-1-methylethyl)pyrrolidine 

Relevant articles and documents

Asymmetric Diels-Alder Reactions with Chiral 1-Azadienes

Chiral 1-azadienes 1 derived from α,β-unsaturated aldehydes and Enders' hydrazines cycloadd to cyclic dienophiles with high facial selectivities.The adducts can be readily converted into enantiomerically pure piperidine derivatives. - Keywords: asymmetric cycloadditions, 1-azadienes, piperidines.

Optically active 3-amino-2H-azirines as synthons for enantiomerically pure α,α-disubstituted α-amino acids: Synthesis of the α-methylphenylalanine synthons and some model peptides

The synthesis of a novel 2-benzyl-2-methyl-3-amino-2H-azirine derivative with a chiral amino group is described. Chromatographic separation of the diastereoisomer mixture yielded the pure diastereoisomers 9a and 9b which are the D- and L-2-methylphenylalanine ((α-Me)Phe) synthons, respectively. The reaction of 9a and 9b with thiobenzoic acid and with Z-leucine yielded the monothiodiamides 10a and 10b and the dipeptide derivatives 11a and 11b, respectively. Methanolysis of 11b yielded 12b. The absolute configuration of 10a was established by X-ray crystallography. The absolute configuration of (α-Me)Phe in 12b has been deduced from the known configuration of L-leucine.

A highly enantioselective synthesis of phosphate triesters

A general methodology for the preparation of both enantiomers of a variety of trialkyl phosphates with enantiomeric excesses ranging from 87 to 92% is described. Bis(2,4-dichlorophenyl) phosphoramidates bearing a 2-substituted pyrrolidine moiety as the chiral auxiliary are prepared and examined for their stereoselectivity. Considerations based on both the absolute configuration of the product phosphates as well as the X-ray structural determination of one of the bis(2,4-dichlorophenyl) phosphoramidates suggest these substitutions occur with preponderant inversion of configuration at phosphorus.

LARGE SCALE PREPARATION OF VERSATILE CHIRAL AUXILIARIES DERIVED FROM (S)-PROLINE

The synthesis of a variety of enantiomerically pure chiral auxiliaries based on (S)-proline and bearing sterically demanding side chains at the pyrrolidine moiety, such as the secondary amines (S)-3,5 and 7 and the hydrazines (S)-6, is described on a molar scale.As key step, the Grignard or RLi addition to the N-benzylated proline ester (S)-1 is used.