118970-92-6

Basic information

• Product Name: (S)-2-(1-BENZYLPYRROLIDIN-2-YL)PROPAN-2-OL
• Synonyms: (S)-2-(1-BENZYLPYRROLIDIN-2-YL)PROPAN-2-OL
• CAS NO: 118970-92-6
• Molecular Formula: C₁₄H₂₁NO
• Molecular Weight: 219.326
• Mol File: 118970-92-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-(1-BENZYLPYRROLIDIN-2-YL)PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(1-BENZYLPYRROLIDIN-2-YL)PROPAN-2-OL(118970-92-6)
• EPA Substance Registry System: (S)-2-(1-BENZYLPYRROLIDIN-2-YL)PROPAN-2-OL(118970-92-6)

Safety Data

• Hazardous Substances Data: 118970-92-6(Hazardous Substances Data)

Usage

General Description

(S)-2-(1-benzylpyrrolidin-2-yl)propan-2-ol is a chemical compound with the molecular formula C16H23NO. It is a chiral alcohol that is commonly used in the synthesis of pharmaceuticals and other organic compounds. The compound contains a pyrrolidine ring, a benzyl group, and a hydroxyl group attached to a propan-2-ol moiety. It has been used in the preparation of various drugs and has shown potential as a chiral auxiliary in asymmetric synthesis. Additionally, it has been investigated for its potential use as a therapeutic agent in the treatment of neurological disorders and mood disorders.

Upstream product

• 75-16-1 methylmagnesium bromide 
• 955-40-8 N-benzyl-L-proline ethyl ester 
• 147-85-3 L-proline 
• 676-58-4 methylmagnesium chloride 
• 113304-84-0 N-benzyl-(S)-proline methyl ester 
• 917-64-6 methyl magnesium iodide 
• 100-39-0 benzyl bromide 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 

Downstream Products

• 92053-25-3 (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine 
• 118970-96-0 (S)-(-)-1-benzyl-2-(1-methoxy-1-methylethyl)-pyrrolidine 
• 41720-99-4 (S)-(-)-2-(1-methylethyl)-pyrrolidine 
• 118971-00-9 (S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine 

Relevant articles and documents

Iminium Catalysis inside a Self-Assembled Supramolecular Capsule: Modulation of Enantiomeric Excess

The noncovalent combination of a supramolecular host with iminium organocatalysis is described. Due to cation–π interactions the reactive iminium species is held inside the host and reacts in this confined environment. The products formed differ up to 92 % ee from the control experiments without added host. A model rationalizing the observed difference is presented.

PYRAZINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS

Pyrazine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

Enantioselective addition of dialkylzinc reagents to N-(diphenylphosphinoyl)imines catalyzed by β-aminoalcohols with the prolinol skeleton

Several β-aminoalcohols with the prolinol framework are shown to be very efficient catalysts for the enantioselective addition of dialkylzinc reagents to N-(diphenylphosphinoyl)imines. The use of 0.5 equiv of the catalyst leads to the expected addition products in good yields and with ee up to 94% in a reaction time of only 4 h at room temperature. This ee is the highest value reported so far using 0.5 equiv of an aminoalcohol as a promoter. High enantioselectivities are obtained in the addition of dialkylzincs to both aromatic and aliphatic imines. The amount of the catalyst can be reduced to 0.25 equiv with a slight decrease in the ee. A very interesting effect of the addition rate and temperature on the enantioselectivity was also observed.