51207-68-2

Usage

Uses

Used in Pharmaceutical Research:
(2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol is used as a building block for the synthesis of pharmaceuticals, leveraging its stability and compatibility with various reaction conditions to facilitate the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol is utilized as a key component in the creation of complex organic compounds, taking advantage of its protected structure to control reaction outcomes and improve synthetic efficiency.
Used in Peptide Synthesis:
(2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol is employed as a protected amino acid in peptide synthesis, allowing for the stepwise assembly of peptide chains with controlled selectivity and minimized side reactions, ultimately leading to the formation of desired peptide sequences.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 
• 74-88-4 methyl iodide 
• 147-85-3 L-proline 
• 474317-28-7 (S)-2-(1-hydroxy-1-methylethyl)pyrrolidine hydrochloride 
• 501-53-1 benzyl chloroformate 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 

Downstream Products

• 77733-65-4 benzyl (S)-2-(2(R)-methyloxiranyl)-1-pyrrolidinecarboxylate 
• 77733-66-5 benzyl (S)-2-(2(S)-methyloxiranyl)-1-pyrrolidinecarboxylate 
• 67016-65-3 Pumiliotoxin B 
• 90246-45-0 (8S,8aS)-8-hydroxy-8-methyl-6(Z)-<4-(benzyloxy)-2(R)-methylbutylidene>octahydroindolizidine 
• 90246-46-1 (1S,7aS)-1-((Z)-(R)-6-Benzyloxy-4-methyl-2-trimethylsilanyl-hex-2-enyl)-1-methyl-tetrahydro-pyrrolo[1,2-c]oxazole 
• 90246-44-9 (1S ,7aS)-tetrahydro-1-methyl-1-<6-(benzyloxy)-4(R)-methyl-2-(trimethylsilyl)-2(Z)-hexenyl>-1H,3H-pyrrolo<1,2-c>oxazol-3-one 
• 90246-49-4 (8S,8aS)-8-hydroxy-8-methyl-6(Z)-<6-oxo-2(R),5-dimethyl-7(R)-(tert-butyldiphenylsiloxy)-4(E)-octenylidene>octahydroindolizidine 
• 129149-57-1 (S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine 
• 118971-00-9 (S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine 
• 313485-22-2 Ethyl (S)-4-[(2'S)-N-(benzyloxycarbonyl)pyrrolidin-2'-yl]-4-hydroxypent-2-ynoate 
• 313485-23-3 Ethyl (R)-4-[(2'S)-N-(benzyloxycarbonyl)pyrrolidin-2'-yl]-4-hydroxypent-2-ynoate 
• 111491-98-6 (2S)-2-Acetyl-N-(benzyloxycarbonyl)pyrrolidine 
• 51207-70-6 (2S)-N-Benzyloxycarbony-2-(1'-methylethenyl)pyrrolidine 
• 92053-25-3 (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine 

Relevant academic research and scientific papers

2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF

[Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, for example, voiding dysfunctions such as underactive bladder.

IDO INHIBITORS

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF

[Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M 3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, for example, voiding dysfunctions such as underactive bladder.

Thiophene derivatives useful as anticancer agents

The invention relates to compounds of the formula 1 or a pharmaceutically acceptable salt and to pharmaceutically acceptable salts and hydrates thereof, wherein X, Y, R1, R2 and R11 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.

A novel approach to the enantioselective formal synthesis of pumiliotoxin 251D

An efficient enantioselective synthesis of the indolizidine framework 9 of pumiliotoxin 251D in good yield by using a Lewis acid (cat.)-promoted diastereoselective addition of ethyl lithiopropiolate to ketone 7 derived from L-proline as a key step is reported. Hydrogenation of the addition product 8a gave the desired lactam 9. At the same time the 8-epimer of 9 was synthesized for the first time.

Unexpected diastereoselectivity in AD of an L-proline-derived 1,1- disubstituted alkene

Asymmetric dihydroxylation of the L-proline-derived 1,1-disubstituted alkene 5 catalysed by either (DHQ)2PHAL or (DHQD)2PHAL unexpectedly leads to preference for the same diastereomer 7, both reactions proceeding with apparently matching double diastereoselectivity. In contrast, AD using the analogous (DHQ)2PYR or (DHQD)2PYR ligands leads to preferences for diols 7 or 8 respectively.

A highly enantioselective synthesis of phosphate triesters

A general methodology for the preparation of both enantiomers of a variety of trialkyl phosphates with enantiomeric excesses ranging from 87 to 92% is described. Bis(2,4-dichlorophenyl) phosphoramidates bearing a 2-substituted pyrrolidine moiety as the chiral auxiliary are prepared and examined for their stereoselectivity. Considerations based on both the absolute configuration of the product phosphates as well as the X-ray structural determination of one of the bis(2,4-dichlorophenyl) phosphoramidates suggest these substitutions occur with preponderant inversion of configuration at phosphorus.