119197-25-0

Basic information

• Product Name: 3-CHLORO-4,4,4-TRIFLUORO-2-PHENYL-BUT-2-ENAL
• Synonyms: 3-CHLORO-3-TRIFLUOROMETHYL-2-PHENYLACROLEINE;3-CHLORO-3-TRIFLUOROMETHYL-2-PHENYL-PROPEN-2-AL;3-CHLORO-4,4,4-TRIFLUORO-2-PHENYL-BUT-2-ENAL
• CAS NO: 119197-25-0
• Molecular Formula: C₁₀H₆ClF₃O
• Molecular Weight: 234.6
• Mol File: 119197-25-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-CHLORO-4,4,4-TRIFLUORO-2-PHENYL-BUT-2-ENAL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4,4,4-TRIFLUORO-2-PHENYL-BUT-2-ENAL(119197-25-0)
• EPA Substance Registry System: 3-CHLORO-4,4,4-TRIFLUORO-2-PHENYL-BUT-2-ENAL(119197-25-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 119197-25-0(Hazardous Substances Data)

Upstream product

• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 
• 68-12-2 N,N-dimethyl-formamide 
• 766-04-1 benzyllithium 

Downstream Products

• 149508-60-1 2-phenyl-3-ethylthio-4,4,4-trifluoromethyl-but-2-en-1-al 
• 136000-11-8 (Z)-2-phenyl-3-ethylthio-4,4,4-trifluoromethyl-but-2-en-1-al 
• 136000-12-9 (E)-2-phenyl-3-ethylthio-4,4,4-trifluoromethyl-but-2-en-1-al 
• 910618-49-4 α-phenyl-2-(trifluoromethyl)thiazolidine-2-acetaldehyde 
• 772-62-3 3,3,3-trifluoro-1-phenylpropyne 
• 34091-69-5 [(1E)-2-chloro-3,3,3-trifluoro-1-propenyl]benzene 
• 34093-70-4 (Z)-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 
• 709-21-7 3,3,3-trifluoro-1-phenylpropan-1-one 
• 142820-53-9 4,4,4-Trifluoro-2-phenyl-butyraldehyde 
• 166657-66-5 (E)-3-Chloro-4,4,4-trifluoro-2-phenyl-but-2-en-1-ol 
• 131124-01-1 (Z)-4,4,4-Trifluoro-3-mercapto-2-phenyl-but-2-enal 
• 133205-47-7 3-phenyl-4-(trifluoromethyl)quinoline 
• 14468-40-7 2-(trifluoromethyl)-1,3-benzothiazole 
• 133205-46-6 3-phenyl-2-trifluoromethyl-1,5-benzothiazepine 

Relevant articles and documents

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Synthesis of CF3-Substituted Quinolines from β-Chloro-β-trifluoromethyl-vinylaldehydes. I.

3-(Trifluoromethyl)-acroleines 2 have been synthesized through VILSMEIER's reaction from α-Trifluoromethylketones 1.The reaction of 2 with anilines and naphthylamines gives in good yields 2-trifluoromethylquinolines 4 and benzoquinolines 5.

Reactivity of β-(trifluoromethyl) acroleins towards primary alkyl (or aryl) amines: synthesis of trifluoromethyl)-1-aza-1,3-dienes and secondary (trifluoromethyl) allylamines

Vilsmeier's reaction on trifluoroketones leads to β-chloro-β(trifluoromethyl)acroleins.The addition of primary alkyl- or aryl-amines to these acroleins leads in all cases to the formation of stable (trifluoromethyl)-1-aza-1,3-dienes which can be transform

Synthesis of γγγ-trifluorocarbonyl compounds

γγγ-Trifluorocarbonyl compounds are easily obtained in a good yield by introduction of the 1,1,1-trifluoroethyl moiety (CF3-CH2-) on the α-methylene group of a ketone.

A new and efficient synthesis of trifluoroalkyl aldehydes or ketones from the same starting material

4,4,4-trifluoroacroleines 2 have been converted specifically by tributyl tin hydride to aldehyders 3 or ketones 4, according to the catalyst and conditions employed.