An efficient kilogram-scale synthesis of N,N2 -bis(4,6-disubstituted 1,3,5-triazin-2-yl)-4-aminophenetylamine
A practical large-scale synthesis was developed for the preparation of N,N2 -bis(4,6-disubstituted 1,3,5-triazin-2-yl)-4-aminophenethylamine derivatives exemplified by compound 2. This route is a sixstep procedure starting from commercially available cyan
USE OF HIGH AFFINITY MONOCLONAL ANTIBODY PRODUCT BINDERS TO INCREASE THE DURATION OF ACTION OF THERAPEUTIC MONOCLONAL ANTIBODY PRODUCTS IN A BIOLOGIC TISSUE
An anchor molecule is provided that (1) binds monoclonal antibody products with high affinity and (2) is anchored in a biologic tissue of interest. Therapeutic antibodies can either be delivered to the biologic tissue before, during, or after the delivery of the anchor molecule. Because the present invention binds monoclonal antibody products and is anchored in a biologic tissue, the result is that monoclonal antibody products are also anchored in a biologic tissue.
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Sheet 25
(2018/03/28)
2,4,6-Trisubstituted triazines as protein A mimetics for the treatment of autoimmune diseases
A first-in-class series of low molecular weight trisubstituted triazines were synthesized and evaluated for their ability tomimic proteinAbinding to human IgGantibody. The structure-activity relationship (SAR) demonstrates that the 1,3-phenylenediamine component was essential for robust activity. Twenty-two compounds, represented by lead molecule 34, displayed significant activity compared to protein A. These compounds may prove useful for the treatment of autoimmune disease.
Zacharie, Boulos,Abbott, Shaun D.,Bienvenu, Jean-Fran?ois,Cameron, Alan D.,Cloutier, Josée,Duceppe, Jean-Simon,Ezzitouni, Abdallah,Fortin, Daniel,Houde, Karine,Lauzon, Caroline,Moreau, Nancie,Perron, Valérie,Wilb, Nicole,Asselin, Michel,Doucet, André,Fafard, Marie-ève,Gaudreau, Dannyck,Grouix, Brigitte,Sarra-Bournet, Fran?ois,St-Amant, Natalie,Gagnon, Lyne,Penney, Christopher L.
experimental part
p. 1138 - 1145
(2010/07/10)
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