1192801-06-1Relevant articles and documents
An efficient kilogram-scale synthesis of N,N2 -bis(4,6-disubstituted 1,3,5-triazin-2-yl)-4-aminophenetylamine
Duceppe, Jean-Simon,Perron, Valerie,Cloutier, Josee,Penney, Christopher,Zacharie, Boulos
, p. 1156 - 1160 (2009)
A practical large-scale synthesis was developed for the preparation of N,N2 -bis(4,6-disubstituted 1,3,5-triazin-2-yl)-4-aminophenethylamine derivatives exemplified by compound 2. This route is a sixstep procedure starting from commercially available cyan
2,4,6-Trisubstituted triazines as protein A mimetics for the treatment of autoimmune diseases
Zacharie, Boulos,Abbott, Shaun D.,Bienvenu, Jean-Fran?ois,Cameron, Alan D.,Cloutier, Josée,Duceppe, Jean-Simon,Ezzitouni, Abdallah,Fortin, Daniel,Houde, Karine,Lauzon, Caroline,Moreau, Nancie,Perron, Valérie,Wilb, Nicole,Asselin, Michel,Doucet, André,Fafard, Marie-ève,Gaudreau, Dannyck,Grouix, Brigitte,Sarra-Bournet, Fran?ois,St-Amant, Natalie,Gagnon, Lyne,Penney, Christopher L.
experimental part, p. 1138 - 1145 (2010/07/10)
A first-in-class series of low molecular weight trisubstituted triazines were synthesized and evaluated for their ability tomimic proteinAbinding to human IgGantibody. The structure-activity relationship (SAR) demonstrates that the 1,3-phenylenediamine component was essential for robust activity. Twenty-two compounds, represented by lead molecule 34, displayed significant activity compared to protein A. These compounds may prove useful for the treatment of autoimmune disease.