119647-69-7

Basic information

• Product Name: ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE
• Synonyms: ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE;1H-Pyrrole-2-carboxylic acid, 4-acetyl-, ethyl ester
• CAS NO: 119647-69-7
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• Mol File: 119647-69-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE(119647-69-7)
• EPA Substance Registry System: ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE(119647-69-7)

Safety Data

• Hazardous Substances Data: 119647-69-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE is used as a building block in organic synthesis for the development of pharmaceuticals. Its unique chemical structure allows it to be incorporated into various drug molecules, contributing to the creation of new and effective medications.
Used in Agrochemical Industry:
ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE is used as a building block in organic synthesis for the production of agrochemicals. Its versatile chemical properties make it suitable for the development of various agrochemical products, such as pesticides and herbicides, to improve crop protection and yield.
Used in Organic Synthesis:
ETHYL 4-ACETYL-1H-PYRROLE-2-CARBOXYLATE is used as a key intermediate in the synthesis of various organic compounds. Its reactivity and functional groups enable chemists to create a wide range of molecules with diverse applications in different industries, including the development of new materials, dyes, and other specialty chemicals.

Upstream product

• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 75-36-5 acetyl chloride 
• 72652-34-7 1-(4-acetyl-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one 
• 141-52-6 sodium ethanolate 
• 108-24-7 acetic anhydride 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 2999-46-4 Ethyl isocyanoacetate 

Downstream Products

• 1072-82-8 3-acetylpyrrole 
• 273382-27-7 1-(5-chloro-2-nitro-benzenesulfonyl)-4-(1-hydroxy-ethyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 273382-37-9 1-(2-amino-5-chloro-benzenesulfonyl)-4-(1-hydroxy-ethyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 273382-24-4 4-acetyl-1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid ethyl ester 

Relevant articles and documents

An efficient highly regioselective synthesis of 2,3,4-trisubstituted pyrroles by cycloaddition of polarized ketene S,S- and N,S-acetals with activated methylene isocyanides

(Chemical Equation Presented) An efficient route for regioselective synthesis of 2,3,4- substituted pyrroles allowing precise control over the introduction of a number of substituents and functionalities (tosyl, carbalkoxy, aryl, cyano, nitro, acetyl, ben

PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY

The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I), Formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

The intramolecular photometathesis of pyrroles

UV irradiation of various electron deficient pyrrole derivatives induces a novel methathesis sequence resulting in selective cleavage of the 2,3-pyrrole bond. The overall sequence has been shown to proceed by two discrete wavelength-dependent steps involving sequential [2+2] cyclobutane formation followed by photochemically mediated retro-[2+2] to the products. Copyright

Cyclo[n]pyrroles and methods thereto

The present invention provides an oxidative coupling procedure that allows efficient synthesis of novel cyclo[n]pyrrole macrocycles. Therefore, the present invention provides cyclo[n]pyrroles where n is 6, 7, 8, 9, 10, 11, or 12, and derivatives, multimers, isomers, and ion and neutral molecule complexes thereof as new compositions of matter. A protonated form of cyclo[n]pyrrole displays a gap of up to 700 nm between strong Soret and Q-like absorption bands in the electronic spectrum, demonstrating no significant ground state absorption in the visible portion of the electronic spectrum. Uses of cyclo[n]pyrroles as separation media, nonlinear optical materials, information storage media and infrared filters are provided.

Aromatic heterocycle compounds having HIV integrase inhibiting activities

A compound of the formula (I): wherein X is hydroxy, protected hydroxy or optionally substituted amino; Y is —COORAwherein RAis hydrogen or ester residue, —CONRBRCwherein RBand RCeach is independently hydrogen or amide residue, optionally substituted aryl or optionally substituted heteroaryl; and A1is optionally substituted heteroaryl; provided that a compound wherein Y and/or A1is optionally substituted indol-3-yl is excluded, a tautomer, a prodrug, a pharmaceutically acceptable salt or a hydrate thereof has an inhibitory activity against an integrase.

β-Acylation of ethyl pyrrole-2-carboxylate by Friedel-Crafts acylation: Scope and limitations (synthetic studies on indoles and related compounds. XXXVIII

The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under several conditions using various Lewis acids and acyl chlorides. The acylation with various acyl chlorides in the presence of aluminum chloride gave exclusively ethyl 4-acylpyrrole-2-carboxylate (5), whereas weaker Lewis acids such as zinc chloride and boron trifluoride etherate gave a mixture of ethyl 4- and 5-acylpyrrole-2-carboxylates.

THE FRIEDEL-CRAFTS ACYLATION OF ETHYL PYRROLE-2-CARBOXYLATE. SCOPE, LIMITATIONS, AND APPLICATION TO SYNTHESIS OF 7-SUBSTITUTED INDOLES

The Friedel-Crafts acylation of ethyl pyrrole-2-carboxylate (3) was studied under a variety of conditions using various Lewis acids and acyl chlorides.The acylation with some Lewis acids such as BF3*OEt2 gave a mixture of 4- and 5-acyl derivatives (5 and