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5-(4-methoxyphenyl)pyrazin-2-amine is an organic compound that serves as a crucial building block in the synthesis of various biologically active molecules. It features a pyrazine core with a 4-methoxyphenyl group attached at the 5th position and an amine functional group at the 2nd position. This unique structure endows it with versatile chemical properties and potential applications in different fields.

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  • 119738-50-0 Structure
  • Basic information

    1. Product Name: 5-(4-methoxyphenyl)pyrazin-2-amine
    2. Synonyms: 5-(4-methoxyphenyl)pyrazin-2-amine
    3. CAS NO:119738-50-0
    4. Molecular Formula: C11H11N3O
    5. Molecular Weight: 201.22454
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 119738-50-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 374.9±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.201±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 3.02±0.10(Predicted)
    10. CAS DataBase Reference: 5-(4-methoxyphenyl)pyrazin-2-amine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-(4-methoxyphenyl)pyrazin-2-amine(119738-50-0)
    12. EPA Substance Registry System: 5-(4-methoxyphenyl)pyrazin-2-amine(119738-50-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 119738-50-0(Hazardous Substances Data)

119738-50-0 Usage

Uses

Used in Pharmaceutical Industry:
5-(4-methoxyphenyl)pyrazin-2-amine is used as a key intermediate in the synthesis of coelenterazine and coelenteramine derivatives. These derivatives exhibit potent inhibitory effects on lipid peroxidation, a process that contributes to cellular damage and various diseases. By incorporating this compound into the synthesis of such inhibitors, it can help develop new therapeutic agents to combat oxidative stress-related conditions.
Used in Chemical Research:
As a versatile building block, 5-(4-methoxyphenyl)pyrazin-2-amine is also used in chemical research for the development of novel compounds with potential applications in various fields. Its unique structure allows for further functionalization and modification, enabling the creation of new molecules with tailored properties and improved performance.

Check Digit Verification of cas no

The CAS Registry Mumber 119738-50-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,7,3 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 119738-50:
(8*1)+(7*1)+(6*9)+(5*7)+(4*3)+(3*8)+(2*5)+(1*0)=150
150 % 10 = 0
So 119738-50-0 is a valid CAS Registry Number.

119738-50-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(4-methoxyphenyl)pyrazin-2-amine

1.2 Other means of identification

Product number -
Other names QC-6896

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119738-50-0 SDS

119738-50-0Relevant articles and documents

Iridium-Catalyzed Asymmetric Hydrogenation of Tosylamido-Substituted Pyrazines for Constructing Chiral Tetrahydropyrazines with an Amidine Skelton

Higashida, Kosuke,Nagae, Haruki,Mashima, Kazushi

supporting information, p. 3949 - 3954 (2016/12/30)

Dinuclear triply chloro-bridged iridium(III) complexes bearing chiral diphosphine ligands catalyze the asymmetric hydrogenation of tosylamido-substituted pyrazines to give the corresponding chiral tetrahydropyrazines with an amidine skeleton in high yield and with high enantioselectivity. Addition of N,N-dimethylanilinium bromide enhanced the catalytic activity of the iridium complexes and also increased the enantioselectivity of the products by trapping the hydrogenated amine products with HBr from N,N-dimethylanilinium bromide. The amidine skeleton of the products could be transformed to give chiral piperazinones and piperazines without loss of enantioselectivity. (Figure presented.).

Direct arylation of n-heteroarenes with aryldiazonium salts by photoredox catalysis in water

Xue, Dong,Jia, Zhi-Hui,Zhao, Cong-Jun,Zhang, Yan-Yan,Wang, Chao,Xiao, Jianliang

supporting information, p. 2960 - 2965 (2014/03/21)

A highly effective visible light-promoted "radical-type" coupling of N-heteroarenes with aryldiazonium salts in water has been developed. The reaction proceeds at room temperature with [Ru(bpy)3]Cl 2×6 H2O as a photosensit

Chemical synthesis of coelenterazine and its analogs: New route by four segment-couplings

Chou, Chun-Ming,Tung, Yu-Wen,Lin, Meng-I,Chan, Diana,Phakhodee, Wong,Isobe, Minoru

, p. 1323 - 1339 (2013/08/15)

A novel and improved synthetic route includes four segment-couplings toward coelenterazine and its analogs as luminescent molecules. Regio- and chemo-selective cross coupling reactions using palladium catalysts with 5-iodo-3-bromo-2-aminopyrazine have enabled providing various aminopyrazine derivatives having different substituents. The improved synthesis of coelenterazine and its analogs employed advanced condensation with the aminopyrazines using various keto-acetal segments, which resulted in much higher yields to give the final imidazopyrazinone heterocycles than the previous method using keto-aldehydes.

New compounds, pharmaceutical compositions and uses thereof

-

Page/Page column 52, (2012/09/05)

The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

IMIDAZO[1,2-α]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE

-

Page/Page column 29, (2011/02/24)

The present invention relates to compound of formula I : and their use as chemiluminescent and/or bioluminescent reagents.

A new class of pyrazolopyridine nucleus with fluorescent properties, obtained through either a radical or a Pd arylation pathway from N-azinylpyridinium N-aminides

Abet, Valentina,Nunez, Araceli,Mendicuti, Francisco,Burgos, Carolina,Alvarez-Builla, Julio

scheme or table, p. 8800 - 8807 (2009/04/11)

(Chemical Equation Presented) The synthesis of dipyridopyrazole and pyridopyrazolopyrazine derivatives - both of which incorporate a 3-aryl moiety - can be achieved in moderate yields by intramolecular radical arylation of pyridinium N-aminides using tris(trimethylsilyl)silane and azobisisobutyronitrile. Improved results were obtained on using Pd direct arylation in conjunction with microwave irradiation. A preliminary study into the fluorescent properties of the target compounds is also reported.

Catechol derivatives of aminopyrazine and cell protection against uvb-induced mortality

Cavalier, Jean-Francois,Burton, Maggi,Dussart, Frederique,Marchand, Cecile,Rees, Jean-Francois,Marchand-Brynaert, Jacqueline

, p. 1037 - 1044 (2007/10/03)

A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte c

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