- GHRELIN O-ACYLTRANSFERASE INHIBITORS
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This invention relates to novel compounds according to Formula (I) which are inhibitors of ghrelin O-acyltransferase (GOAT), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment
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Page/Page column 67; 68
(2019/08/26)
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- Synthesis of novel hydrazone and azole functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents
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A series of novel pyrazolo[3,4-b]pyridine based target compounds were synthesized starting from the key intermediate ethyl 2-(3-amino-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate 5 on reaction with hydrazine hydrate followed by reaction with
- Nagender,Naresh Kumar,Malla Reddy,Krishna Swaroop,Poornachandra,Ganesh Kumar,Narsaiah
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p. 4427 - 4432
(2016/08/25)
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- Synthesis of novel pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives and their cytotoxic activity
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The 3-amino-6-(trifluoromethyl)furo[2,3-b]pyridine-2-carbohydrazide (5) was prepared from 3-cyano-6-trifluoromethyl-2(1H)pyridone (2) in series of steps via selective O-alkylation, Thorpe-Ziegler cyclization followed by reaction with hydrazine hydrate. The 2-carbohydrazide (5) was further reacted with aliphatic acids under different reaction temperatures to form a series of novel N-acylfuro[2,3-b]pyridine-2-carbohydrazide (6) and pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives (7). All the compounds 6 and 7 were screened for cytotoxic activity against breast carcinoma MD Anderson-Metastatic Breast (MDA-MB) 231 (aggressive) cell lines at 10 μM concentration. Compounds 6a, 6b, and 6c showed promising activity.
- Naresh Kumar,Malla Reddy,Nagendar,Kurumurthy,Shanthan Rao,Karnewar, Santosh,Kotamraju, Srigiridhar,Narsaiah
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p. 1531 - 1535
(2015/04/27)
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- USE of PYRIDINE-2-OXY-3-CARBOXAMIDES AS SAFENERS
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According to the invention, compounds of the general formula (I) or salts thereof (pyridine-2-oxy-3-carboxamides), in which R1 is a (C1-C4)-haloalkyl radical can be employed as safeners, i.e. as agents for preventing or reducing phytotoxic effects of pesticides, preferably herbicides, on useful plants.
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Page/Page column 24-25
(2008/12/04)
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- PYRIDINECARBOXAMIDES, USEFUL-PLANT-PROTECTING COMPOSITION COMPRISING THEM AND PROCESSES FOR THEIR PREPARTION AND THEIR USE
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Compounds of the formula (I), or salts thereof, in which R1 to R4 are as defined in formula (I) of claim 1 are suitable as useful-plant-protecting agents for reducing or preventing harmful effects of agrochemicals on the useful plants and their method of preparation are described.
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Page/Page column 18-19
(2008/12/04)
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- Difluorinated Danishefsky's Diene: A versatile C4 building block for the fluorinated six-membered rings
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(equation presented) A Mg(0)/Me3SiCl system was found to be affective for the preparation of difluoro Danishefsky's dienes 2, which involves selective C-F bond cleavage of trifluoromethyl ketones 3. Subsequent hetero Diels-Alder reactions of 2 with aldehydes and imines gave a variety of fluorinated six-membered heterocycles.
- Amii, Hideki,Kobayashi, Takeshi,Terasawa, Hiroshi,Uneyama, Kenji
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p. 3103 - 3105
(2007/10/03)
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