120717-41-1

Basic information

• Product Name: Pyrimidine, 5-ethenyl-2-methoxy- (9CI)
• Synonyms: Pyrimidine, 5-ethenyl-2-methoxy- (9CI)
• CAS NO: 120717-41-1
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.15122
• Product Categories: PYRIMIDINE
• Mol File: 120717-41-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimidine, 5-ethenyl-2-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 5-ethenyl-2-methoxy- (9CI)(120717-41-1)
• EPA Substance Registry System: Pyrimidine, 5-ethenyl-2-methoxy- (9CI)(120717-41-1)

Safety Data

• Hazardous Substances Data: 120717-41-1(Hazardous Substances Data)

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 90905-32-1 2-methoxy-pyrimidine-5-carbaldehyde 
• 108-05-4 vinyl acetate 
• 14001-66-2 5-bromo-2-methoxypyrimidine 
• 7486-35-3 tri-n-butyl(vinyl)tin 

Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent

A nickel-catalyzed reductive cross-coupling has been achieved using (hetero)aryl bromides and vinyl acetate as the coupling partners. This mild, applicable method provides a reliable access to a variety of vinyl arenes, heteroarenes, and benzoheterocycles, which should expand the chemical space of precursors to fine chemicals and polymers. Importantly, a sustainable solvent, dimethyl isosorbide, is used, making this protocol more attractive from the point of view of green chemistry.

2-Cyanophenyl fused heterocyclic compounds, and compositions and uses thereof

Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Syntheses of 5-Alkenylpyrimidines by Organotin Reactions

5-Stannylpyrimidines can be prepared from the corresponding bromides by lithiation at -95 deg C and quenching with tributylstannyl chloride.The 5-stannyl-pyrimidine is used in Pd-catalyzed coupling reactions with vinyl bromides.The opposite reaction sequence, i.e.Pd-catalyzed coupling between 5-halopyrimidines and vinyltin derivatives, is also described.Alternatively, the 5-vinylpyrimidines have been obtained by dehydrohalogenation with cesium fluoride and by a modified Wittig reaction. 2-Methylthiopyrimidines are transformed into the 2-methoxy derivatives or 2-pyrimidinones using chloramine-T (CAT) in a simple one-pot synthesis.