General Procedures for the Lithiation/Trapping of N-Boc Piperazines
To provide α-substituted piperazines for early stage medicinal chemistry studies, a simple, general synthetic approach is required. Here, we report the development of two general and simple procedures for the racemic lithiation/trapping of N-Boc piperazin
Firth, James D.,O'Brien, Peter,Ferris, Leigh
p. 7023 - 7031
(2017/07/17)
Synthesis of piperazine derivatives by Cp (*)Ir complex-catalyzed N-alkylative reactions of ethanolamines
A new method for the synthesis of piperazine derivatives catalyzed by a Cp (*)Ir complex has been developed. Cp (*)Ir complex-catalyzed N-alkylative homocoupling reactions of N-benzylethanolamines give N,N'-dibenzylpiperazine derivatives. For example, the
Fujita, Ken-Ichi,Kida, Yasushi,Yamaguchi, Ryohei
experimental part
p. 1371 - 1377
(2010/10/03)
1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS
Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
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Page/Page column 31
(2010/11/29)
N-aryl-piperazinealkanamides useful for improving sleep
A method of improving sleep in warm-blooded animals suffering from sleep disorders, which method comprises the administration of particular N-aryl-piperazinealkanamide derivatives and compositions containing the same. Novel N-aryl-piperazinealkanamide derivatives.
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(2008/06/13)
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