Tert-butyl 4-benzyl-2-methylpiperazine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-benzyl-2-methylpiperazine-1-carboxylate
CAS No.:120737-77-1
Molecular Formula:C17H26 N2 O2
Molecular Weight:290.406
Hs Code.:
European Community (EC) Number:692-579-7
DSSTox Substance ID:DTXSID00568014
Nikkaji Number:J2.686.132B
Mol file:120737-77-1.mol

Synonyms:120737-77-1;tert-butyl 4-benzyl-2-methylpiperazine-1-carboxylate;4-BENZYL-2-METHYLPIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperazinecarboxylicacid, 2-methyl-4-(phenylmethyl)-, 1,1-dimethylethyl ester;TERT-BUTYL-4-BENZYL-2(R)-METHYL-PIPERAZINECARBOXYLATE;SCHEMBL3664002;DTXSID00568014;ZPDZNQZBTLCTDV-UHFFFAOYSA-N;4-benzyl-2-methylpiperazine-1-carboxylic acidtert-butyl ester;VEA73777;AB3317;MFCD03265484;AKOS005256165;AB14249;CS-0324801;AU-004/43508705;tert-butyl 4-benzyl-2-methyl-1-piperazinecarboxylate;(1,1-dimethylethyl) 2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate;(1,1-dimethylethyl) 2methyl-4-(phenylmethyl)-1-piperazinecarboxylate;4-Benzyl-2-methylpiperazine-1-carboxylic acid tert-butyl ester, AldrichCPR

Suppliers and Price of Tert-butyl 4-benzyl-2-methylpiperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Benzyl-2-methylpiperazine-1-carboxylic acid tert-butyl ester
100mg
$ 60.00

SynChem
1-Benzyl-4-boc-piperazine 95%
10 g
$ 200.00

SynChem
1-Benzyl-4-boc-piperazine 95%
1 g
$ 40.00

SynChem
1-Benzyl-4-boc-piperazine 95%
5 g
$ 120.00

Sigma-Aldrich
4-Benzyl-2-methylpiperazine-1-carboxylic acid tert-butyl ester Aldrich
1g
$ 83.50

Matrix Scientific
4-Benzyl-2-methylpiperazine-1-carboxylic acidtert-butyl ester 97%
1g
$ 68.00

Matrix Scientific
4-Benzyl-2-methylpiperazine-1-carboxylic acidtert-butyl ester 97%
5g
$ 238.00

Chemenu
tert-butyl4-benzyl-2-methylpiperazine-1-carboxylate 95%
1g
$ 690.00

American Custom Chemicals Corporation
4-BENZYL-2-METHYLPIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%
5MG
$ 497.75

Alfa Aesar
4-Benzyl-1-Boc-2-methylpiperazine, 97%
1g
$ 61.60

Total 16 raw suppliers

Chemical Property of Tert-butyl 4-benzyl-2-methylpiperazine-1-carboxylate

Chemical Property:

Melting Point:71-73 °C(lit.)
Refractive Index:1.527
Boiling Point:371.5°Cat760mmHg
Flash Point:178.5°C
PSA：32.78000
Density:1.059g/cm³
LogP:3.00360
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:290.199428076
Heavy Atom Count:21
Complexity:345

Purity/Quality:

98%min ^*data from raw suppliers

4-Benzyl-2-methylpiperazine-1-carboxylic acid tert-butyl ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CN(CCN1C(=O)OC(C)(C)C)CC2=CC=CC=C2

Technology Process of Tert-butyl 4-benzyl-2-methylpiperazine-1-carboxylate

There total 4 articles about Tert-butyl 4-benzyl-2-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 3138-90-7
3-methyl-1-(phenylmethyl)piperazine

: 120737-77-1
tert-butyl 2-methyl-4-benzyl-1-piperazinecarboxylate

Guidance literature:: di-tert-butyl dicarbonate; 3-methyl-1-(phenylmethyl)piperazine; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 74.0%

: 57260-70-5
4-benzyl-piperazine-1-carboxylic acid tert-butyl ester

: 74-88-4
methyl iodide

: 120737-77-1
tert-butyl 2-methyl-4-benzyl-1-piperazinecarboxylate

Guidance literature:: 4-benzyl-piperazine-1-carboxylic acid tert-butyl ester; With sec.-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.75h; Inert atmosphere;
DOI:10.1021/acs.joc.7b00913

Reference yield: 56.0%

: 1145656-20-7
C₁₀H₂₁NO₄

: 100-46-9
benzylamine

: 120737-77-1
tert-butyl 2-methyl-4-benzyl-1-piperazinecarboxylate

Guidance literature:: With dichloro(pentamethylcyclopentadienyl) iridium; sodium hydrogencarbonate; In toluene; at 110 ℃; for 17h; Inert atmosphere;
DOI:10.3987/COM-08-S(F)77