3138-90-7

Basic information

• Product Name: 1-Benzyl-3-methylpiperazine
• Synonyms: N-1-BENZYL-3-METHYL-PIPERAZINE;RAC 1-BENZYL-3-METHYL-PIPERAZINE >98%;1-BENZYL-3-METHYL-PIPERAZINE (RAC);1-Benzyl-3-methyl-piperazine ,98%;alpha-(3-Methylpiperazin-1-yl)toluene;3-Methyl-1-(phenylMethyl)piperazine;3-Methyl-1-(phenylMethyl)-piperazine;3-Methyl-1-benzyl-piperazine
• CAS NO: 3138-90-7
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• EINECS: 604-604-1
• Product Categories: pharmacetical;Piperazine series
• Mol File: 3138-90-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 125-126℃/2mm
• Flash Point: 112.3 °C
• Appearance: /
• Density: 0.991 g/cm³
• Vapor Pressure: 0.00354mmHg at 25°C
• Refractive Index: 1.529
• Solubility: Methanol
• PKA: 9.31±0.40(Predicted)
• CAS DataBase Reference: 1-Benzyl-3-methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-3-methylpiperazine(3138-90-7)
• EPA Substance Registry System: 1-Benzyl-3-methylpiperazine(3138-90-7)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-20/21/22
• Safety Statements: 45-24/25-23
• HazardClass: IRRITANT
• Hazardous Substances Data: 3138-90-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

3-Methyl-1-benzyl-piperazine is piperazine derivative used in the preparation of piperazinylpyrimidines as tranquilizers.

InChI:InChI=1/C12H18N2/c1-11-9-14(8-7-13-11)10-12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3

Upstream product

• 109-07-9 (RS)-2-methylpiperazine 
• 584-08-7 potassium carbonate 
• 100-44-7 benzyl chloride 
• 98-88-4 benzoyl chloride 
• 78-98-8 2-oxopropanal 
• 4152-09-4 N-benzylethylenediamine 

Downstream Products

• 80827-71-0 8-[4-(2-Methyl-4-[phenylmethyl]-1-piperazinyl)-butyl]-8-azaspiro[4.5]decane-7,9-dione 
• 214748-88-6 4-Benzyl-1-{3-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-2-methyl-piperazine 
• 314729-18-5 1-benzoyl-4-benzyl-2-methylpiperazine 
• 120737-77-1 tert-butyl 2-methyl-4-benzyl-1-piperazinecarboxylate 
• 1391602-61-1 (4-benzyl-2-methyl-piperazin-1-yl)-pyrrolidin-1-yl-methanone 
• 1346681-91-1 benzyl (R)-4-benzyl-2-methylpiperazine-1-carboxylate 
• 1417826-87-9 (S)-1-(4-benzyl-2-methylpiperazin-1-yl)-3-phenylpropan-1-one 
• 120737-78-2 tert-butyl 2-methylpiperazine-1-carboxylate 
• 132871-11-5 (R)-3-Methyl-1-(phenylmethyl)piperazine 
• 1346681-92-2 (S)-4-benzyl-1-(3-mesitylpropanoyl)-2-methylpiperazine 
• 313657-09-9 3-Chloro-2-(4-benzyl-2-methyl-1-piperazinyl)pyrazine 
• 109-07-9 (RS)-2-methylpiperazine 

Relevant articles and documents

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.

SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted pyridinyl-pyrimidines of formula 1 wherein ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O, wherein R1, R2, R4, R3, R5 and R6 are defined as in claim 1 and wherein ring A is further optionally substituted by one or two further substituents and the pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates and solvates of the aforementioned compounds.

1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS

Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.