121193-17-7

Basic information

• Product Name: Benzamide, 4-propyl- (9CI)
• Synonyms: Benzamide, 4-propyl- (9CI)
• CAS NO: 121193-17-7
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• Product Categories: AMIDE
• Mol File: 121193-17-7.mol

Chemical Properties

• Boiling Point: 295.186 °C at 760 mmHg
• Flash Point: 132.324 °C
• Appearance: /
• Density: 1.037 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: Benzamide, 4-propyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-propyl- (9CI)(121193-17-7)
• EPA Substance Registry System: Benzamide, 4-propyl- (9CI)(121193-17-7)

Safety Data

• Hazardous Substances Data: 121193-17-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzamide, 4-propyl(9CI) is employed as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of organic molecules with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, Benzamide, 4-propyl(9CI) serves as a starting material for the production of specific materials. Its versatile chemical properties make it a valuable component in the development of new materials with diverse applications.
Used in Medicinal Chemistry Research:
Benzamide, 4-propyl(9CI) is utilized in medicinal chemistry research to explore its potential as a precursor for the development of new drugs. Its unique structure may contribute to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Pharmaceutical Development:
In the field of pharmaceutical development, Benzamide, 4-propyl(9CI) may be used to investigate its potential applications in drug design and optimization. Further research is necessary to understand its properties and explore its use in creating new pharmaceutical agents with enhanced therapeutic benefits.

InChI:InChI=1/C10H13NO/c1-2-3-8-4-6-9(7-5-8)10(11)12/h4-7H,2-3H2,1H3,(H2,11,12)

Upstream product

• 52710-27-7 4-propylbenzoyl chloride 
• 103-65-1 phenylpropane 
• 2438-05-3 4-n-propylbenzoic acid 
• 28785-06-0 4-n-propylbenzaldehyde 

Downstream Products

• 1313711-79-3 methyl 4-methyl-2-(4-propylphenyl)thiazole-5-carboxylate 
• 1225606-49-4 4-propylbenzothioamide 
• 1537168-35-6 2-{1-[4-methyl-2-(4-propylphenyl)thiazol-5-yl]ethylidene}-hydrazinecarboximidamide 
• 1537168-56-1 1-[4-methyl-2-(4-propylphenyl)thiazol-5-yl]ethanone 

Relevant articles and documents

A Molecular Iron-Based System for Divergent Bond Activation: Controlling the Reactivity of Aldehydes

The direct synthesis of amides and nitriles from readily available aldehyde precursors provides access to functional groups of major synthetic utility. To date, most reliable catalytic methods have typically been optimized to supply one product exclusively. Herein, we describe an approach centered on an operationally simple iron-based system that, depending on the reaction conditions, selectively addresses either the C=O or C-H bond of aldehydes. This way, two divergent reaction pathways can be opened to furnish both products in high yields and selectivities under mild reaction conditions. The catalyst system takes advantage of iron's dual reactivity capable of acting as (1) a Lewis acid and (2) a nitrene transfer platform to govern the aldehyde building block. The present transformation offers a rare control over the selectivity on the basis of the iron system's ionic nature. This approach expands the repertoire of protocols for amide and nitrile synthesis and shows that fine adjustments of the catalyst system's molecular environment can supply control over bond activation processes, thus providing easy access to various products from primary building blocks.

Method for preparing derivatives of benzamide under microwave condition in aqueous phase

The invention discloses a method for preparing derivatives of benzamide under a microwave condition in an aqueous phase. A coupling reaction is carried out between substituted benzoic acid and amine under the microwave condition in the aqueous phase. The method for preparing the derivatives of benzamide is environmentally friendly, easy and convenient to operate, safe, low in cost and efficient. Compared with the prior art, the method can be applicable to a large number of functional groups, is high in yield, produces fewer by-products, and further is easy to operate, safe, low in cost and environmentally friendly. A formula is shown in the description.

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 μg/mL.

ANTIMICROBIAL SUBSTITUTED THIAZOLES AND METHODS OF USE

Disclosed are compositions having activity against MRSA and/or VRSA, and methods of using the compositions to treat microbial infections.