121409-45-8

Upstream product

• 40428-86-2 sodium adeninate 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 65551-68-0 potassium adeninate 
• 82039-68-7 C₅H₄N₅^(1-)*Li⁽¹⁺⁾ 
• 13222-85-0 p-methylbenzoic anhydride 
• 958-09-8 2'-deoxy-D-adenosine 
• 66224-66-6 adenine 
• 1228304-65-1 C₃₅H₄₂N₆O₅ 

Downstream Products

• 849936-57-8 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythropentofuranosyl]-6-fluoropurine 
• 328378-38-7 9-[2-deoxy-3,5-di-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-6-(4-fluorophenyl)purine 

Relevant academic research and scientific papers

Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions

Amidine-type protecting groups, i.e., N,N-dimethylformamidine (dmf) and N,N-dibutylformamidine (dbf) groups, introduced into nucleobases were rapidly removed under mild acidic conditions using imidazolium triflate (IMT) or 1-hydroxybenztriazole (HOBt). This new deprotection strategy allowed a 2′-O-methyl-RNA derivative bearing a base-labile group to be efficiently synthesized using a silyl-type linker. It was also found that our new method could be applied to the synthesis of an unmodified RNA oligomer.

Nucleic acid related compounds. 127. Selective N-deacylation of N,O-peracylated nucleosides in superheated methanol

Solutions of peracylated adenosine, cytidine, and related nucleoside derivatives undergo selective N-deacylation upon heating at elevated temperatures (oil bath ≥ 105 °C) in methanol. An increase in the bulk of the N-acyl group has little effect on the rate of N-deacylation but increases the N/O selectivity ratio. Extended heating is required for N-deacylation with arylcarboxylic acid derivatives. Contamination with acidic or basic reagent residues is avoided.

(S,S)-(+)-pseudoephedrine as chiral auxiliary in asymmetric aza-Michael reactions. Unexpected selectivity change when manipulating the structure of the auxiliary

The asymmetric aza-Michael reaction of metal benzylamides to α,β-unsaturated amides derived from the chiral amino alcohol (S,S)-(+)-pseudoephedrine has been studied in detail. A deep study of the most important experimental parameters (solvent, temperatur

THE SYNTHESIS OF 2'-DEOXYADENOSINE VIA STEREOSPECIFIC COUPLING REACTION

The coupling reaction of the sodium salt of adenine, which could be easily prepared by deprotonation with sodium hydroxide or sodium methoxide, with 1-α-chloro-2-deoxyribose derivative proceeded in a good stereospecific manner in acetone as a solvent to give the β-anomer of the corresponding acylated adenosine.