121933-59-3Relevant articles and documents
A SYNTHESIS OF 4,7-DIHYDRO-1H-DIPYRROLOPYRROLE AND 4,7-DIHYDRO-4H-THIENOPYRROLOPYRROLE SYSTEMS
Aratani, Tadatoshi,Yoshihara, Hiroshi,Suzukamo, Gohfu
, p. 1655 - 1656 (1989)
The titled two systems (3 and 6), both new members of linearly fused heteroaromatics, were prepared using pyrrolo-annulation reaction: condensation of an aromatic aldehyde with azidoacetate followed by thermolysis of the resulting azidoacrylate.
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models
Romussi, Alessia,Cappa, Anna,Vianello, Paola,Brambillasca, Silvia,Cera, Maria Rosaria,Dal Zuffo, Roberto,Fagà, Giovanni,Fattori, Raimondo,Moretti, Loris,Trifirò, Paolo,Villa, Manuela,Vultaggio, Stefania,Cecatiello, Valentina,Pasqualato, Sebastiano,Dondio, Giulio,So, Chi Wai Eric,Minucci, Saverio,Sartori, Luca,Varasi, Mario,Mercurio, Ciro
, p. 754 - 759 (2020)
Lysine-specific demethylase 1 (LSD1 or KDM1A) is a FAD-dependent enzyme that acts as a transcription corepressor or coactivator by regulating the methylation status of histone H3 lysines K4 and K9, respectively. KDM1A represents an attractive target for c
Self-condensation of N-substituted (4H-thieno[3,2-b]-pyrrol-5-yl)methanols into bis(thienopyrrolyl)methanes
Torosyan, Seda A.,Zagitov, Vadim V.,Gimalova, Fanuza A.,Biglova, Raisa Z.,Miftakhov, Mansur S.
, p. 192 - 194 (2018)
N-Substituted (4H-thieno[3,2-b]pyrrol-5-yl)methanols were obtained by alkylation of methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate followed by reduction with LiAlH4. These compounds on contact with Amberlyst 15 (H-form) in CH2Cl2
Synthesis of N-Substituted Methyl 4H-Thieno[3,2-b]pyrrole-5-carboxylates
Torosyan,Gimalova,Zagitov,Erastov,Miftakhov
, p. 912 - 917 (2018/07/31)
The alkylation of methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate with methyl iodide and allyl, propargyl, and benzyl bromides in the presence of sodium hydride in THF afforded the corresponding N-substituted derivatives. Some reactions of the alkylation products were studied.