1221186-55-5

Basic information

• Product Name: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate
• Synonyms: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate;4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 2-bromo-6-formyl-4-methyl-, ethyl ester;2-Bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester
• CAS NO: 1221186-55-5
• Molecular Formula: C11H10BrNO3S
• Molecular Weight: 316.171
• Mol File: 1221186-55-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(1221186-55-5)
• EPA Substance Registry System: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate(1221186-55-5)

Safety Data

• Hazardous Substances Data: 1221186-55-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate serves as a key intermediate in the synthesis of novel pharmaceutical agents. Its unique structural elements, including the bromine atom and the formyl group, can be leveraged to create a variety of bioactive molecules with potential therapeutic applications. ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate's ability to be modified and functionalized makes it a versatile building block in the design of new drugs.
Used in Organic Synthesis:
In the realm of organic synthesis, ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate is utilized as a valuable precursor for the creation of diverse organic compounds. Its reactivity and the presence of multiple functional groups allow for a wide range of chemical reactions, facilitating the synthesis of complex organic molecules with specific properties and applications.
Used in Medicinal Chemistry:
Ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate is employed in medicinal chemistry for the exploration of its biological activities. Given its structural complexity, it may exhibit interesting pharmacological properties, such as binding affinity to specific biological targets or modulating cellular pathways. This makes it a candidate for further study in the development of new therapeutic agents.
Used in Chemical Biology:
In chemical biology, ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate can be used as a tool compound to probe the mechanisms of biological processes. Its unique structure may allow it to interact with biological molecules in ways that can provide insights into disease pathways or cellular functions, contributing to a better understanding of biological systems and the discovery of new therapeutic targets.

Upstream product

• 1221186-54-4 ethyl 2-bromo-6-formyl-4H-thieno[3,2-b]pyrrole-5-carboxylate 
• 74-88-4 methyl iodide 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 1421933-23-4 ethyl (Z)-2-azido-3-(5-bromo-2-thienyl)prop-2-enoate 
• 238749-50-3 ethyl 2-bromothieno<3,2-b>pyrrole-5-carboxylate 

Downstream Products

• 1221186-56-6 2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one 

Relevant articles and documents

THIENO[3,2-B] PYRROLE[3,2-D]PYRIDAZINONE DERIVATIVES AND THEIR USE AS PKM2 DERIVATIVES FOR THE TREATMENT OF CANCER, OBESITY AND DIABETES RELATED DISORDERS

Described herein are compounds that regulate pyruvate kinase activity, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R2, L1-L2, U1-U7, m, ring A, and Q are as defined herein.

ACTIVATORS OF HUMAN PYRUVATE KINASE

Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R1 to R16 are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer and anemia, Formulas (I); (II).

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

Cancer cells have distinct metabolic needs that are different from normal cells and can be exploited for development of anti-cancer therapeutics. Activation of the tumor specific M2 form of pyruvate kinase (PKM2) is a potential strategy for returning cancer cells to a metabolic state characteristic of normal cells. Here, we describe activators of PKM2 based upon a substituted thieno[3,2-b]pyrrole[3,2-d]pyridazinone scaffold. The synthesis of these agents, structure-activity relationships, analysis of activity at related targets (PKM1, PKR and PKL) and examination of aqueous solubility are investigated. These agents represent the second reported chemotype for activation of PKM2.