ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

Base Information

• Chemical Name: ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate
• CAS No.: 1221186-55-5
• Molecular Formula: C11H10BrNO3S
• Molecular Weight: 316.17
• Mol file: 1221186-55-5.mol

Synonyms:ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

Chemical Property of ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

Chemical Property:

• PSA: 76.54000
• LogP: 2.99150

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

There total 4 articles about ethyl 2-broMo-6-forMyl-4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl 2-bromo-6-formyl-4H-thieno[3,2-b]pyrrole-5-carboxylate (1221186-54-4) + methyl iodide (74-88-4) → ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate (1221186-55-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

5-bromo-2-thiophencarboxaldehyde (4701-17-1) → ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate (1221186-55-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium ethanolate / ethanol / 1.5 h / -10 - 0 °C

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 0.17 h / 160 °C

3.1: trichlorophosphate / 1,2-dichloro-ethane / 0 - 85 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

4.2: 2 h / 0 - 20 °C

With sodium ethanolate; sodium hydride; trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

ethyl (Z)-2-azido-3-(5-bromo-2-thienyl)prop-2-enoate (1421933-23-4) → ethyl 2-bromo-6-formyl-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylate (1221186-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 5,5-dimethyl-1,3-cyclohexadiene / 0.17 h / 160 °C

2.1: trichlorophosphate / 1,2-dichloro-ethane / 0 - 85 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 2 h / 0 - 20 °C

With sodium hydride; trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 2-bromo-6-formyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

methyl iodide

5-bromo-2-thiophencarboxaldehyde

ethyl (Z)-2-azido-3-(5-bromo-2-thienyl)prop-2-enoate

Downstream raw materials:

2-bromo-4-methyl-4H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5(6H)-one