122135-81-3Relevant articles and documents
Towards a facile synthesis of triarylethanones: Palladium-catalyzed arylation of ketone enolates under homogeneous and heterogeneous conditions
Churruca, Fátima,SanMartin, Raul,Carril, Mónica,Tellitu, Imanol,Domínguez, Esther
, p. 2393 - 2408 (2004)
The palladium-catalyzed regioselective α-monoarylation of deoxybenzoins and α,α-diarylation of acetophenones provides general, efficient access to 1,2,2-triarylethanones. After a comprehensive search for suitable experimental conditions to optimize such transformations, both reactions are alternatively conducted by means of either commercially available polymer-anchored catalysts or a very simple homogeneous catalytic system, thus avoiding the use of complex ligands. In addition, the synthesis of deoxybenzoins employing polymer-supported fibrous palladium catalysts is reported for the first time, and the excellent catalyst recycling properties suggest applicability to industrial purposes.
Regioselective diarylation of ketone enolates by homogeneous and heterogeneous catalysis: Synthesis of triarylethanones
Churruca, Fátima,SanMartin, Raul,Tellitu, Imanol,Domínguez, Esther
, p. 5925 - 5929 (2003)
A novel, one-step approach to 1,2,2-triarylethanones is achieved by an efficient palladium-catalyzed α,α-diarylation of commercially available acetophenones. After assaying an array of experimental conditions, two convenient procedures, which avoid ortho-arylation side reactions, are chosen to perform the target regioselective diarylation. The former protocol is based on the use of such a simple homogeneous system as Pd(OAc)2/PPh3/Cs2CO3, and the latter one employs a commercially available polymer-anchored catalyst, FibreCat 1026.
Aqueous α-Arylation of Mono- and Diarylethanone Enolates at Low Catalyst Loading
Astarloa, Iratxe,SanMartin, Raul,Herrero, María Teresa,Domínguez, Esther
supporting information, p. 1711 - 1718 (2018/03/21)
Acetophenone and deoxybenzoin derivatives are selectively α-arylated using a combination of very small amounts of palladium acetate and diphenylphosphine oxide as catalyst system and water as the only solvent. Target di- and triarylethanones are isolated virtually free of metal residues, and the reaction is amenable to gram-scale. A mechanistic proposal based on TEM images, poisoning experiments, kinetic plot and ESI-MS spectrometry is also provided. (Figure presented.).
Palladium-catalysed direct synthesis of benzo[b]thiophenes from thioenols
Inamoto, Kiyofumi,Arai, Yukari,Hiroya, Kou,Doi, Takayuki
supporting information; experimental part, p. 5529 - 5531 (2009/04/13)
The one-pot conversion of thioenols into benzo[b]thiophenes was achieved by using a simple palladium catalyst such as PdCl2 or PdCl 2(cod). The Royal Society of Chemistry.
