Ethanone, 2,2-bis(3-methoxyphenyl)-1-phenyl-

Base Information

• Chemical Name: Ethanone, 2,2-bis(3-methoxyphenyl)-1-phenyl-
• CAS No.: 122135-81-3
• Molecular Formula: C22H20 O3
• Molecular Weight: 332.399
• DSSTox Substance ID: DTXSID80153528
• Nikkaji Number: J1.922.429E
• Wikidata: Q83020440
• Mol file: 122135-81-3.mol

Synonyms:BRN 3622502;2,2-Bis(3-methoxyphenyl)-1-phenylethanone;Ethanone, 2,2-bis(3-methoxyphenyl)-1-phenyl-;122135-81-3;DTXSID80153528;LS-67202;alpha,alpha-Bis(3-methoxyphenyl)acetophenone

Chemical Property of Ethanone, 2,2-bis(3-methoxyphenyl)-1-phenyl-

Chemical Property:

• Vapor Pressure: 1.55E-09mmHg at 25°C
• Boiling Point: 484.4°C at 760 mmHg
• Flash Point: 239°C
• Density: 1.132g/cm³
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 332.14124450
• Heavy Atom Count: 25
• Complexity: 392

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)C(C2=CC(=CC=C2)OC)C(=O)C3=CC=CC=C3

Technology Process of Ethanone, 2,2-bis(3-methoxyphenyl)-1-phenyl-

There total 3 articles about Ethanone, 2,2-bis(3-methoxyphenyl)-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-methoxyphenyl bromide (2398-37-0) + acetophenone (98-86-2) → 2,2-bis(3-methoxyphenyl)-1-phenylethan-1-one (122135-81-3)

Guidance literature:

With potassium phosphate; tetrabutylammomium bromide; water; palladium diacetate; Diphenylphosphine oxide; In 1,4-dioxane; at 160 ℃; Inert atmosphere;

DOI:10.1002/adsc.201701596

Reference yield:

3-methoxyphenyl bromide (2398-37-0) + acetophenone (98-86-2) → 1′-(3-methoxyphenyl)-2′-phenylethan-2′-one (29955-26-8) + 2,2-bis(3-methoxyphenyl)-1-phenylethan-1-one (122135-81-3)

Guidance literature:

With FibreCat^TM 1026; caesium carbonate; In N,N-dimethyl-formamide; at 153 ℃; Further Variations:; Reagents; Reaction partners; Product distribution;

DOI:10.1016/S0040-4039(03)01398-4

Reference yield:

3-methoxyphenyl bromide (2398-37-0) + acetophenone (98-86-2) + triphenylphosphine (603-35-0) → 1′-(3-methoxyphenyl)-2′-phenylethan-2′-one (29955-26-8) + 2,2-bis(3-methoxyphenyl)-1-phenylethan-1-one (122135-81-3) + 2-(3-methoxyphenyl)-1,2-diphenylethanone

Guidance literature:

With palladium(II) trifluoroacetate; caesium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 1.5h; Further Variations:; Reagents; Product distribution;

DOI:10.1016/j.tet.2003.12.065

upstream raw materials:

3-methoxyphenyl bromide

acetophenone

triphenylphosphine

Downstream raw materials:

2,2-bis(3-methoxyphenyl)-1-phenylethenethiol