122159-58-4

Basic information

• Product Name: 3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE
• Synonyms: AKOS BAR-1395;3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE
• CAS NO: 122159-58-4
• Molecular Formula: C11H7F3S
• Molecular Weight: 228.23
• Mol File: 122159-58-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE(122159-58-4)
• EPA Substance Registry System: 3-(3-TRIFLUOROMETHYL-PHENYL)-THIOPHENE(122159-58-4)

Safety Data

• Hazardous Substances Data: 122159-58-4(Hazardous Substances Data)

Upstream product

• 872-31-1 3-Bromothiophene 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 10486-61-0 3-thienyl iodide 
• 188290-36-0 thiophene 
• 455-14-1 4-trifluoromethylphenylamine 
• 6165-69-1 Thien-3-ylboronic acid 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Relevant articles and documents

Redox-Divergent Construction of (Dihydro)thiophenes with DMSO

Thiophene-based rings are one of the most widely used building blocks for the synthesis of sulfur-containing molecules. Inspired by the redox diversity of these features in nature, we demonstrate herein a redox-divergent construction of dihydrothiophenes, thiophenes, and bromothiophenes from the respective readily available allylic alcohols, dimethyl sulfoxide (DMSO), and HBr. The redox-divergent selectivity could be manipulated mainly by controlling the dosage of DMSO and HBr. Mechanistic studies suggest that DMSO simultaneously acts as an oxidant and a sulfur donor. The synthetic potentials of the products as platform molecules were also demonstrated by various derivatizations, including the preparation of bioactive and functional molecules.

Synthesis of Biaryls through Nickel-Catalyzed Suzuki-Miyaura Coupling of Amides by Carbon-Nitrogen Bond Cleavage

The first Ni-catalyzed Suzuki-Miyaura coupling of amides for the synthesis of widely occurring biaryl compounds through N-C amide bond activation is reported. The reaction tolerates a wide range of electron-withdrawing, electron-neutral, and electron-donating substituents on both coupling partners. The reaction constitutes the first example of the Ni-catalyzed generation of aryl electrophiles from bench-stable amides with potential applications for a broad range of organometallic reactions. Breaking and making: The first nickel-catalyzed Suzuki-Miyaura coupling of amides for the synthesis of biaryl compounds through N-C amide bond cleavage is reported. The reaction tolerates a wide range of sensitive and electronically diverse substituents on both coupling partners.

AgONO-Assisted Direct C-H Arylation of Heteroarenes with Anilines

A novel copper-catalyzed C-H arylation of heteroarenes with anilines by an in situ diazonium reaction is established by using silver nitrite (AgONO) as an unconventional nitrosating reagent under acid-free conditions. It provides a complementary approach for the C-H arylation of electron-rich heteroarenes with aromatic amines affording a variety of heterobiaryls in moderate to good yields.

Water-soluble palladium nanoparticles: Click synthesis and applications as a recyclable catalyst in Suzuki cross-couplings in aqueous media

A new PEG-tagged material, which was prepared by a threefold copper-catalyzed [3+2] cycloaddition (click chemistry), was found to act as an efficient stabilizer for palladium nanoparticles. The newly formed material proved to be active asa recyclable catalyst in Suzuki coupling the presence of polyether chains allowed for the catalytic runs to be conducted in aqueous media.

PPAR active compounds

Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.