1223546-54-0

Basic information

• Product Name: C₁₉H₁₅ClFN₃O
• Synonyms: C₁₉H₁₅ClFN₃O
• CAS NO: 1223546-54-0
• Molecular Weight: 355.799
• Mol File: 1223546-54-0.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₅ClFN₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₅ClFN₃O(1223546-54-0)
• EPA Substance Registry System: C₁₉H₁₅ClFN₃O(1223546-54-0)

Safety Data

• Hazardous Substances Data: 1223546-54-0(Hazardous Substances Data)

Upstream product

• 84857-18-1 4-(4-Fluoro-phenyl)-6-p-tolyl-pyrimidin-2-ylamine 
• 79-04-9 chloroacetyl chloride 
• 122-00-9 para-methylacetophenone 
• 13565-38-3 (E)-3-(4-fluorophenyl)-1-(p-tolyl)prop-2-en-1-one 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1223546-59-5 N-(4-(4-methylphenyl)-6-(4-fluorophenyl)pyrimidin-2-yl)-2-morpholinoacetamide 
• 1377325-07-9 C₂₄H₂₆FN₅O 

Relevant articles and documents

A facile microwave-assisted "one-Pot" synthesis of piperazino pyrimidinyl acetamides, a class of hybrid bis heterocycles and their structural elucidation using NMR spectral techniques

An array of novel piperazino pyrimidinyl acetamides, a class of hybrid bis heterocycles are synthesized in "one-pot" by microwave irradiation method catalyzed by heterogeneous NaHSO4.SiO2 catalyst in dry media and are characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H and 13C) and two-dimensional 1H-1H COSY and 1H-13C HSQC spectral data.

Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides

Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 have been synthesized and evaluated for their in vitro antibacterial and antifungal activities. The minimum inhibitory concentration tested for the same compounds against the same set of bacterial and fungal strains shows that the compounds 36 and 38 against β-Heamolytic streptococcus and Klebsiella pneumonia, 40 against Escherichia coli and Pseudomonas, have excellent antibacterial activity. Compounds 36, 38 and 42 show inhibition against Aspergillus flavus, compound 41 against Microsporum gypsuem, 42 against Mucor, and compounds 39 and 40 against Rhizopus.

Design, synthesis and spectral characterization of novel 2-morpholino-n-(4,6-diarylpyrimidin-2-yl)acetamides

A new series of novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 is synthesized by the condensation of 2-chloro-N-(4,6-diarylpyrimidin-2- yl)acetamides 25-33 with morpholine in the presence of anhydrous potassium carbonate. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H & 13C) spectroscopic data.