84857-18-1

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 113-00-8 guanidine nitrate 
• 459-57-4 4-fluorobenzaldehyde 
• 122-00-9 para-methylacetophenone 
• 13565-38-3 (E)-3-(4-fluorophenyl)-1-(p-tolyl)prop-2-en-1-one 
• 506-93-4 guanidine nitrate 
• 51477-09-9 1-(4-fluorophenyl)-3-(p-tolyl)prop-2-en-1-one 
• 50-01-1 guanidine hydrochloride 
• 13565-38-3 3-(4-fluorophenyl)-1-p-tolylprop-2-en-1-one 

Downstream Products

• 1223546-54-0 C₁₉H₁₅ClFN₃O 
• 1377325-07-9 C₂₄H₂₆FN₅O 
• 1229405-51-9 C₁₈H₁₅FN₄O 

Relevant academic research and scientific papers

Acceptorless Dehydrogenative Synthesis of Pyrimidines from Alcohols and Amidines Catalyzed by Supported Platinum Nanoparticles

A one-pot, acceptorless dehydrogenative method, using a carbon-supported Pt catalyst (Pt/C) along with KOtBu, has been developed for the synthesis of 2,4,6-trisubstituted pyrimidines from secondary and primary alcohols, and amidines. The reaction takes place efficiently using a wide range of substrate scopes (32 examples with isolated yields up to 92%). The Pt/C catalyst that promotes this process is reusable and has a higher turnover number (TON) than those employed in previously reported methods. The results of mechanistic studies suggest that the process takes place through a pathway that begins with Pt-catalyzed acceptorless dehydrogenation of the alcohol substrate, which is followed by sequential condensation, cyclization, and dehydrogenation. Measurements of the turnover frequency combined with the results of density functional theory calculations on different metal surfaces suggest that the adsorption energy of H on the Pt surface is optimal for the acceptorless dehydrogenation process, which causes the higher catalytic activity of Pt over those of other metals.

A facile microwave-assisted "one-Pot" synthesis of piperazino pyrimidinyl acetamides, a class of hybrid bis heterocycles and their structural elucidation using NMR spectral techniques

An array of novel piperazino pyrimidinyl acetamides, a class of hybrid bis heterocycles are synthesized in "one-pot" by microwave irradiation method catalyzed by heterogeneous NaHSO4.SiO2 catalyst in dry media and are characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H and 13C) and two-dimensional 1H-1H COSY and 1H-13C HSQC spectral data.

Synthesis and in vitro microbiological evaluation of an array of biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides

Biolabile 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 have been synthesized and evaluated for their in vitro antibacterial and antifungal activities. The minimum inhibitory concentration tested for the same compounds against the same set of bacterial and fungal strains shows that the compounds 36 and 38 against β-Heamolytic streptococcus and Klebsiella pneumonia, 40 against Escherichia coli and Pseudomonas, have excellent antibacterial activity. Compounds 36, 38 and 42 show inhibition against Aspergillus flavus, compound 41 against Microsporum gypsuem, 42 against Mucor, and compounds 39 and 40 against Rhizopus.

Design, synthesis and spectral characterization of novel 2-morpholino-n-(4,6-diarylpyrimidin-2-yl)acetamides

A new series of novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 is synthesized by the condensation of 2-chloro-N-(4,6-diarylpyrimidin-2- yl)acetamides 25-33 with morpholine in the presence of anhydrous potassium carbonate. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H & 13C) spectroscopic data.

Synthesis and in-vitro antimicrobial activity of 4,6 disubstituted pyrimidines

This paper describes the synthesis and evaluation of antimicrobial profile of new 2-amino 4,6 disubstituted pyrimidines and 2-mercapto 4,6 disubstituted pyrimidines. Our results show that the 2-mercapto 4,6 disubstituted pyrimidines are active against Mycobacterium tuberculosis at 10 μg mL-1, whereas the corresponding 2-amino-4,6 disubstituted pyrimidines are devoid of antitubercular activity. All the compounds were devoid of antibacterial and antifungal activity.

Reaction of α,β-Unsaturated Ketones with Guanidine. Substituent Effects on the Protonation Constants of 2-Amino-4,6-diarylpyrimidines

1.3-Diaryl-2-propen-1-ones, I, reacted with guanidine hydrochloride (II) in the presence of 3 moles of sodium hydroxide to give the corresponding 2-amino-4,6-diarylpyrimidines, III.The structure and configuration of the products are based on chemical and