123-03-5 Usage
Uses
Used in Oral Care Products:
Cetylpyridinium chloride is used as an antiseptic and antimicrobial agent in mouthwashes and lozenges for the treatment of minor infections of the mouth and throat. It is effective against bacteria such as S. mutans, S. sanguis, E. coli, Oxford Staphylococcus, and C. albicans, as well as inhibiting plaque formation for at least 21 days when applied topically at concentrations ranging from 0.025 to 2%.
Used in Pharmaceutical Industry:
Cetylpyridinium chloride is used as a preservative in the pharmaceutical industry due to its quaternary ammonium compound nature. It helps maintain the stability and safety of various products by preventing microbial contamination.
Used in Cosmetics:
In the cosmetics industry, CPC is used as a preservative to ensure the longevity and safety of products. Its antimicrobial properties help prevent the growth of harmful microorganisms that could cause infections or spoilage.
Used in Raw Food Processing:
Cetylpyridinium chloride is used as an antimicrobial agent in raw food processing to maintain the quality and safety of the products. It helps prevent the growth of harmful bacteria and extends the shelf life of the food items.
Used in Cough Lozenges and Syrups:
Cetylpyridinium chloride is used as an antibacterial agent in cough lozenges and syrups to help treat respiratory infections and soothe throat irritation.
Used as an Emulsifier:
CPC is also utilized as an emulsifier in various industries, including pharmaceuticals and cosmetics, to help blend and stabilize mixtures of oil and water.
Used on the Surface of Latex Gloves:
Cetylpyridinium chloride is used as a topical anti-infective and disinfectant on the surface of latex gloves, providing an additional layer of protection against the transmission of infections.
Brand Names:
Some well-known brand names for products containing cetylpyridinium chloride include Ceepryn (Marion Merrell Dow) and Cepacol (Marion Merrell Dow).
Production Methods
Cetylpyridinium chloride is prepared from cetyl chloride by
treatment with pyridine.
Flammability and Explosibility
Nonflammable
Pharmaceutical Applications
Cetylpyridinium chloride is a quaternary ammonium cationic
surfactant, used in pharmaceutical and cosmetic formulations as
an antimicrobial preservative. It is used therapeutically
as an antiseptic agent; used alone or in combination with
other drugs for oral and throat care; used in nonparenteral
formulations licensed in the UK; and used in oral and inhalation
preparations at concentrations of 0.02–1.5 mg.
Mouthwashes containing cetylpyridinium chloride have been
shown to inhibit plaque formation,(1–3) although efficacy is variable
owing to limited published data.
Clinical Use
1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In this compound, thequaternary nitrogen atom is a member of an aromatic pyridinering.The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.
Safety Profile
Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. Moderately toxic by skin
contact. A skin and eye irritant. When
E heated to decomposiuon it emits very toxic
fumes of NOx and Cl-.
Safety
Cetylpyridinium chloride is used widely in mouthwashes as a
bactericidal antiseptic. It is generally regarded as a relatively
nontoxic material when used at a concentration of 0.05% w/v,
although minor side effects such as mild burning sensations on the
tongue have been reported.
At higher concentrations, cetylpyridinium chloride may damage
the mucous membranes in the mouth. It is harmful when ingested or
inhaled. It can cause eye irritation, and is irritant to the respiratory
system and the skin.
LD50 (rat, IP): 0.006 g/kg
LD50 (rat, IV): 0.03 g/kg
LD50 (rat, oral): 0.2 g/kg
LD50 (rat, SC): 0.25 g/kg
LD50 (mouse, IP): 0.01 g/kg
LD50 (mouse, oral): 0.108 g/kg
LD50 (rabbit, oral): 0.4 g/kg
LD50 (rabbit, IV): 0.036 g/kg
storage
Cetylpyridinium chloride is stable under normal conditions. It
should be stored in well-closed containers.
Incompatibilities
Incompatible with strong oxidizing agents and bases. It is also
incompatible with methylcellulose.
Magnesium stearate suspensions in cetylpyridinium chloride
have been shown to significantly reduce its antimicrobial activity.
This is due to the absorption of cetylpyridinium chloride on
magnesium stearate. The cetylpyridinium chloride ion also
interacts with gelatin, resulting in reduced bioavailability.
Regulatory Status
Included in nonparenteral formulations licensed in the UK. Included
in the FDA Inactive Ingredients Database, for use in inhalation and
oral preparations. Reported in the EPA TSCA Inventory. It is not
approved for use in Japan. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
Check Digit Verification of cas no
The CAS Registry Mumber 123-03-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 123-03:
(5*1)+(4*2)+(3*3)+(2*0)+(1*3)=25
25 % 10 = 5
So 123-03-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H38N.2ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-22-20-17-15-18-21-22;;/h15,17-18,20-21H,2-14,16,19H2,1H3;2*1H/q+1;;/p-2
123-03-5Relevant articles and documents
Surfactant Aggregation Number and Polydispersity of SDS + 1-Pentanol Mixed Micelles in Brine Determined by Time-Resolved Fluorescence Quenching
Lang, Jacques
, p. 3734 - 3739 (1990)
Size and polydispersity of sodium dodecyl sulfate (SDS) + 1-pentanol direct mixed micelles have been investigated by means of the time-resolved fluorescence quenching method in the system SDS/1-pentanol/water/NaCl ( = 0.0331 M, = 0.42 M, and = 6.5 g/L of water).This method reveals high polydispersity in micellar size.Several size distribution models have been tested.The one that best fits the data is a double Gaussian distribution which suggests that two populations of mixed micelles might be present in the solution, centered on the SDS mean aggregation numbers of 75 and 830.
AN IMPROVED PROCESS FOR PREPARATION OF QUATERNARY PYRIDINIUM SALTS
-
Page/Page column 11; 12, (2019/08/08)
The present invention discloses a process for the production of quaternary pyridinium salts and hydrates thereof. In this process, Cetylpyridinium chloride monohydrate with high purity and yield is obtained by reacting Cetyl chloride, pyridine, and water and Laurylpyridinium chloride monohydrate with high purity and yield is obtained by reacting Lauryl chloride, pyridine, and water. The process disclosed herein is simple, cost-effective and eco-friendly and produces quaternary pyridinium salts and hydrates thereof having high purity and yield at industrial scale.
AN IMPROVED PROCESS FOR THE PRODUCTION OF QUATERNARY PYRIDINIUM SALTS
-
Page/Page column 8, (2016/06/28)
Disclosed herein is cost effective and eco-friendly process for producing quaternary pyridinium salts and their hydrates thereof, with high yield and purity at industrial scale.
STABLE COMPOSITIONS OF THIABENDAZOLE AND IODINE-CONTAINING FUNGICIDES
-
, (2015/02/25)
The present invention relates to stable compositions for the fungicidal equipment of thermoplastic polymers, in particular PVC, comprising thiabendazole, at least one iodine-containing fungicide and at least one epoxide and optionally further fungicidally active compounds, and also to methods for preparing these formulations and to uses thereof for the protection of thermoplastic polymers against attack and destruction by microorganisms. Moreover, the invention relates to mold-resistant PVC materials equipped with the compositions according to the invention.
FUNGICIDAL PENFLUFEN MIXTURES
-
, (2014/04/03)
The invention relates to mixtures comprising penflufen, to the use of these mixtures for protecting industrial materials and to a method for treating industrial materials with the penflufen mixtures.
One-pot synthesis of cationic amphiphiles from n-alcohols and allyl alcohols
Narender, Tadigoppula,Madhur, Gaurav,Dharamsheela,Reddy, K. Papi,Sarkar,Sarkar,Tripathi
supporting information; experimental part, p. 1687 - 1692 (2011/09/14)
A novel, efficient one-pot method has been developed to synthesize amphiphiles such as N-alkylated/N-allylated triethyl-amines and pyridinium salts for the first time from n-alcohols and naturally occurring terpenes (allyl alcohols) in good yields. These amphiphiles have got industrial application as surfactants, DNA carriers, and other biological applications. The DNA delivery efficacy and cytotoxicity of N-alkylated and N-allylated triethylamine and pyridinium salts were studied. Georg Thieme Verlag Stuttgart · New York.
Oral Moisturizer for Alleviating Dry Mouth
-
, (2010/02/17)
An oral moisturizer is disclosed to provide relief from dry mouth. The moisturizer may be provided in different flavors that are palatable, with clinical benefits such as anti-nausea, appetite stimulant, etc., in addition to relief from the deteriorating dental effects of dry mouth. One disclosed oral moisturizer includes glycerin, xylitol, sodium hyaluronate, cetylpyridinium chloride, polysorbate surfactants and a palatable flavor.
Synergetic biocidal composition comprising 2-methylisothiazoline-3-on
-
, (2008/06/13)
The invention relates to a biocidal composition which can be added to materials which can be attacked by harmful micro-organisms. The composition comprises 2-methylisothiazoline-3-on as biocidal active ingredient and at least one other biocidal active ingredient. The biocidal composition is characterised in that the composition contains formaldehyde or a formaldehyde-depot material, 2-brom-2-nitro-1,3 propandiol, polyhexamethylene biguanide, o-phenylphenol, pyrithione, n-butyl-1,2-benzisothiazoline-3-on, n-hydroxymenthyl-1,2-benzisothiazoline-3-on or benzalkonium chloride as said other biocidal active ingredient.
Synergistic biocide composition
-
, (2008/06/13)
A biocide composition is provided as an addition to substances that can be infected by harmful microorganisms, in which the biocide composition has at least two active biocidal substances, one of which is 2-methylisothiazolin-3-one. The composition is characterized in that it contains 1,2-benzisothiazolin-3-one, compositions containing 5-chloro-2-methylisothiazolin-3-one being excluded. In comparison with its individual components, the composition of the invention has a synergistic biocidal activity.
Liquid-crystalline ionic liquids
Bowlas, Christopher J.,Bruce, Duncan W.,Seddon, Kenneth R.
, p. 1625 - 1626 (2007/10/03)
Low-melting point salts, the basis of industrially relevant ionic liquids, exhibit smectic A mesophases over extended temperature ranges.
