123792-59-6Relevant articles and documents
INVERSE ELECTRON DEMAND DIELS-ALDER REACTIONS OF 5-NITROPYRIMIDINE WITH ENAMINES. SYNTHESIS OF 3-NITROPYRIDINE DERIVATIVES
Marcelis, Antonius T. M.,Plas, Henk C. van der
, p. 2693 - 2702 (1989)
The reaction of cyclic and non-cyclic enamines with 5-nitropyrimidine has been studied.Many enamines react in an inverse electron-demand Diels-Alder reaction, leading to the formation of 3-nitropyridines.N,S-ketene acetals were also found to react with 5-nitropyrimidines.The mechanism of the reaction will be discussed.
An efficient synthesis of nitrated cycloalka[ b ]pyridines
Le, Thi Song,Asahara, Haruyasu,Nishiwaki, Nagatoshi
, p. 2175 - 2178 (2014)
The three-component ring transformation of 1-methyl-3,5-dinitro-2-pyridone with cycloalkanones of different ring sizes in the presence of ammonium acetate affords the corresponding nitrated cycloalka[b]pyridines in high yields. Furthermore, a double bond can be easily introduced into the product by changing the cycloalkanone into a cycloalkenone. Georg Thieme Verlag Stuttgart. New York.
Synthesis, Characterization, and Rapid Cycloadditions of 5-Nitro-1,2,3-triazine
Glinkerman, Christopher M.,Boger, Dale L.
supporting information, p. 2628 - 2631 (2018/05/17)
The synthesis, characterization, and a study of the cycloaddition reactions of 5-nitro-1,2,3-triazine (3) are reported. The electron-deficient nature of 3 permits rapid cycloaddition with a variety of electron-rich dienophiles, including amidines, enamines, enol ethers, ynamines, and ketene acetals in high to moderate yields. 1H NMR studies of a representative cycloaddition reaction between 3 and an amidine revealed a remarkable reaction rate and efficiency (1 mM, 3CN, 23 °C, >95%).
Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents
Vara Prasad,Boyer, Frederick E.,Chupak, Lou,Dermyer, Michael,Ding, Qizhu,Gavardinas,Hagen, Susan E.,Huband, Michael D.,Jiao, Wenhua,Kaneko, Takushi,Maiti, Samarendra N.,Melnick, Michael,Romero, Karina,Patterson,Wu, Xiujuan
, p. 5392 - 5397 (2007/10/03)
We describe a novel class of benzocycloheptanone derived oxazolidinone antibacterial agents. The synthesis and antibacterial activities with structure variation is discussed.
ANTIBACTERIAL AGENTS
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Page 138, (2010/02/08)
Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
Synthesis and structure-activity relationships of fused imidazopyridines: A new series of benzodiazepine receptor ligands
Takada, Susumu,Sasatani, Takashi,Chomei, Nobuo,Adachi, Makoto,Fujishita, Toshio,Eigyo, Masami,Murata, Shunji,Kawasaki, Kazuo,Matsushita, Akira
, p. 2844 - 2851 (2007/10/03)
2-Arylimidazo[4,5-c]quinolines and analogous fused imidazopyridines were synthesized and evaluated as benzodiazepine receptor ligands. Affinity to the receptors was greatly affected by the bulkiness of the aryl group at the 2- position, compared to the pyrazoloquinolines such as CGS-9896. Derivatives with an isoxazole moiety at the 2-position showed high binding affinity and in vivo activity. In the imidazo[4,5-c]quinoline series, substitution at the 6-position decreased or abolished activity. Most derivatives with an unsubstituted isoxazolyl group showed antagonist or inverse agonist activity except for the 7-halo analogues, which exhibited agonist activity. On the other hand, 5-methylisoxazol-3-yl or 3-methylisoxazol-5-yl derivatives generally exhibited agonist activity. A similar substitution effect on the isoxazole moiety was observed in the imidazopyridines fused with a nonaromatic ring. From the detailed pharmacological evaluation, S-8510, 2- (3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine monophosphate, possessing weak inverse agonist activity was selected as a therapeutic candidate for the treatment of some symptoms of senile dementia.
