1239647-60-9

Basic information

• Product Name: 6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine
• Synonyms: 6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine
• CAS NO: 1239647-60-9
• Molecular Formula: C6H5ClN4
• Molecular Weight: 169
• Mol File: 1239647-60-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine(1239647-60-9)
• EPA Substance Registry System: 6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine(1239647-60-9)

Safety Data

• Hazardous Substances Data: 1239647-60-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
6-Chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine is employed as a key intermediate in the synthesis of new drug candidates. Its structure allows for the exploration of its interactions with different biological targets, which is crucial for identifying potential therapeutic agents.
Used in Drug Discovery:
In the pharmaceutical industry, 6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine is used as a tool for drug discovery. The presence of the chlorine atom and the amine group in its molecule provides unique opportunities for chemical modifications, which can enhance its binding affinity to specific targets, thereby increasing its potential as a lead compound in drug development.
Used in Medicinal Chemistry:
6-Chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine serves as a versatile building block in medicinal chemistry. Its chemical properties can be exploited to design and develop novel compounds with improved pharmacological profiles, including better potency, selectivity, and pharmacokinetic properties.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 78852-50-3 ethyl [(5-chloropyridin-2-yl)carbamothioyl]carbamate 

Downstream Products

• 1443763-66-3 (2R)-N-{4-[2-({4-[(3-fluoroazetidin-1-yl)carbonyl]-2-methoxyphenyl}amino)-[1,2,4]triazolo[1,5-α]pyridin-6-yl]phenyl}-2-(4-fluorophenyl)propanamide 
• 1443763-71-0 (2R)-2-amino-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)-phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]ethanamide 
• 1443763-62-9 (2R)-2-(4-fluorophenyl)-N-[4-(2-{[4-(methylsulfonyl)-2-(2,2,2-trifluoroethoxy)phenyl]amino}[1,2,4]triazolo[1,5-α]pyridin-6-yl)phenyl]propanamide 
• 1403330-47-1 2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]acetamide 
• 1403331-13-4 N-(2,4-difluorobenzyl)-4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide 
• 1443763-88-9 tert-butyl [4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]-triazolo[1,5-α]pyridin-6-yl)phenyl]carbamate 
• 1443763-89-0 6-(4-aminophenyl)-N-[2-methoxy-4-(methylsulfonyl)phenyl][1,2,4]triazolo[1,5-α]pyridin-2-amine 
• 1443764-09-7 tert-butyl [(1R)-1-(4-fluorophenyl)-2-{[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]amino}-2-oxoethyl]carbamate 
• 1443763-60-7 (2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5,α]pyridin-6-yl)phenyl]propanamide 

Relevant articles and documents

METHOD FOR PREPARING SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.

METHOD FOR PREPARING SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to methods o f preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.

SUBSTITUTED TRIAZOLOPYRIDINES HAVING ACTIVITY AS MPS-1 INHIBITORS

The present invention relates to substituted triazolopyridine compounds of general formula (I), in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or prophylaxis of diseases.