1443763-60-7

Basic information

• Product Name: Mps1-IN-5
• Synonyms: Mps1-IN-5;BAY 1161909;Benzeneacetamide, 4-fluoro-N-[4-[2-[[2-methoxy-4-(methylsulfonyl)phenyl]amino][1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]-α-methyl-, (αR)-
• CAS NO: 1443763-60-7
• Molecular Formula: C₂₉H₂₆FN₅O₄S
• Molecular Weight: 559.6112432
• Product Categories: API
• Mol File: 1443763-60-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 13.71±0.70(Predicted)
• CAS DataBase Reference: Mps1-IN-5(CAS DataBase Reference)
• NIST Chemistry Reference: Mps1-IN-5(1443763-60-7)
• EPA Substance Registry System: Mps1-IN-5(1443763-60-7)

Safety Data

• Hazardous Substances Data: 1443763-60-7(Hazardous Substances Data)

Usage

General Description

Mps1-IN-5 is a chemical compound that functions as a potent and selective inhibitor of the protein Mps1, also known as monopolar spindle 1. Mps1 is a key regulator of the spindle assembly checkpoint, and its inhibition can lead to mitotic arrest and cell death in cancer cells. Mps1-IN-5 has shown promising results in preclinical studies as a potential anti-cancer agent, particularly in cancers with chromosomal instability and high levels of aneuploidy. Its specificity and potency make it a valuable tool for studying the role of Mps1 in cancer progression and for developing targeted cancer therapeutics. Further research and clinical trials are needed to fully evaluate the potential of Mps1-IN-5 as a cancer treatment.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 150360-26-2 (2R)-2-(4-fluorophenyl)propanoic acid 
• 78852-50-3 ethyl [(5-chloropyridin-2-yl)carbamothioyl]carbamate 
• 1239647-60-9 6-chloro[1,2,4]triazolo[1,5-α]pyridin-2-amine 
• 1539264-88-4 6-chloro-N-[2-methoxy-4-(methylsulfonyl)phenyl][1,2,4]triazolo[1,5-α]pyridin-2-amine 
• 1539264-91-9 (2R)-2-(4-fluorophenyl)-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanamide 
• 1539264-92-0 (4-{[(2R)-2-(4-fluorophenyl)propanoyl]amino}phenyl)boronic acid 
• 1539264-96-4 (2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)boronic acid 
• 1539264-97-5 (2R)-N-(4-bromophenyl)-2-(4-fluorophenyl)propanamide 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 380430-49-9 [4-(tert-butoxycarbonylamino)phenyl]boronic acid 
• 1443763-88-9 tert-butyl [4-(2-{[2-methoxy-4-(methylsulfonyl)phenyl]amino}[1,2,4]-triazolo[1,5-α]pyridin-6-yl)phenyl]carbamate 
• 90531-98-9 1-bromo-2-methoxy-4-(methylsulfonyl)benzene 
• 450-88-4 1-bromo-4-fluoro-2-methoxybenzene 

Relevant articles and documents

METHOD FOR PREPARING SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.

PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES

The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or prophylaxis of diseases.