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CAS

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123994-79-6

2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one, also known as napabucasin, is a chemical compound with potential anticancer and anti-inflammatory properties. It is characterized by its ability to inhibit the STAT3 signaling pathway, which plays a crucial role in regulating cell growth and survival.

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  • 123994-79-6 Structure

  • Basic information

    1. Product Name: 2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one
    2. Synonyms: 1H-purin-6-ol, 2-(2-naphthalenylamino)-; 2-(naphthalen-2-ylamino)-1H-purin-6-ol
    3. CAS NO:123994-79-6
    4. Molecular Formula: C15H11N5O
    5. Molecular Weight: 277.2807
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 123994-79-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 619.6°C at 760 mmHg
    3. Flash Point: 328.5°C
    4. Appearance: N/A
    5. Density: 1.53g/cm3
    6. Vapor Pressure: 2.81E-15mmHg at 25°C
    7. Refractive Index: 1.803
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one(123994-79-6)
    12. EPA Substance Registry System: 2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one(123994-79-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 123994-79-6(Hazardous Substances Data)

123994-79-6 Usage

Uses

Used in Oncology:
2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one is used as an anticancer agent for its potential in treating various types of cancer. It targets the STAT3 signaling pathway, which is often dysregulated in cancer cells, leading to uncontrolled cell growth and resistance to apoptosis. 2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one has been studied for its efficacy against colorectal, pancreatic, and breast cancer, among others.
Used in Inflammatory Conditions:
2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one is used as an anti-inflammatory agent due to its potential to alleviate symptoms of inflammatory bowel disease and other inflammatory conditions. Its ability to modulate the immune response and reduce inflammation makes it a promising candidate for the treatment of such disorders.
Used in Drug Development:
2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one is used as a therapeutic agent in the development of new drugs for cancer and inflammatory conditions. Ongoing research and clinical trials are focused on evaluating its safety, efficacy, and potential synergistic effects when combined with other treatments. 2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one shows promise as a valuable addition to the arsenal of available treatments for these challenging health issues.

Check Digit Verification of cas no

The CAS Registry Mumber 123994-79-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,9 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 123994-79:
(8*1)+(7*2)+(6*3)+(5*9)+(4*9)+(3*4)+(2*7)+(1*9)=156
156 % 10 = 6
So 123994-79-6 is a valid CAS Registry Number.

123994-79-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(naphthalen-2-ylamino)-3,7-dihydropurin-6-one

1.2 Other means of identification

Product number -
Other names 6H-Purin-6-one,1,9-dihydro-2-(2-naphthalenylamino)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123994-79-6 SDS

123994-79-6Downstream Products

123994-79-6Relevant articles and documents

Structure-Activity Relationships of N2-Substituted Guanines as Inhibitors of HSV1 and HSV2 Thymidine Kinases

Hildebrand, Catherine,Sandoli, Daniele,Focher, Federico,Gambino, Joseph,Ciarrocchi, Giovanni,et al.

, p. 203 - 206 (2007/10/02)

A series of N2-phenylguanines was synthesized and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2.Compounds with hydrophobic, electron-attracting groups in the meta position of the phenyl ring

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