87781-93-9

Usage

Uses

Used in Biochemical Research:
2-Bromohypoxanthine is used as a research tool in the fields of genetics and pharmacology for [application reason], facilitating the study of biological processes and the development of therapeutic agents.
Used in Chemical Synthesis:
In the chemical industry, 2-Bromohypoxanthine is used as an intermediate for [application reason], enabling the creation of more complex compounds that may have various applications in medicine and other fields.

InChI:InChI=1/C5H3BrN4O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H2,7,8,9,10,11)

Upstream product

• 2487-40-3 2-mercapto-1,9-dihydro-6H-purin-6-one 
• 50-69-1 D-ribose 
• 77-76-9 2,2-dimethoxy-propane 
• 2487-40-3 6-hydroxy-2-mercaptopurine 

Downstream Products

• 252719-81-6 2-(1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-6-ol 
• 1042917-83-8 6-hydroxy-2-[3-(4-morpholino)phenyl]amino-9H-purine 
• 83173-14-2 N²-(p-n-butylphenyl)guanine 
• 123994-82-1 2-hexylamino-6-hydroxypurine 
• 123994-76-3 2-(3,4-Dibromo-phenylamino)-1,9-dihydro-purin-6-one 
• 142581-06-4 2-((4-chlorophenyl)amino)-1,9-dihydro-6H-purin-6-one 
• 123994-67-2 2-(3-Chloro-phenylamino)-1,9-dihydro-purin-6-one 
• 142580-99-2 2-(3-Iodo-phenylamino)-1,9-dihydro-purin-6-one 
• 123994-69-4 2-(3-Ethyl-phenylamino)-1,9-dihydro-purin-6-one 
• 123994-81-0 2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-one 
• 142581-00-8 2-(3-Bromo-phenylamino)-1,9-dihydro-purin-6-one 
• 123994-73-0 2-(4-Ethyl-phenylamino)-1,9-dihydro-purin-6-one 
• 142581-05-3 2-(4-Iodo-phenylamino)-1,9-dihydro-purin-6-one 
• 123994-72-9 p-BrPG 

Relevant academic research and scientific papers

POTASSIUM CHANNEL MODULATORS

Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with potassium channels.

Nucleoside and DNA adducts from N-nitrosotolazoline

The reaction of N-nitrosotolazoline, the nitrosation product of a representative imidazoline receptor drug tolazoline, with DNA, deoxyguanosine (dG), or deoxyadenosine (dA) produces adducts containing the 2-phenylacetamidoethyl group. The synthesis and ch

2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives

A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2areceptor are described.

N2-amination of guanine to 2-hydrazinohypoxanthine, a novel in vivo nucleic acid modification produced by the hepatocarcinogen 2-nitropropane

2-Nitropropane, an industrial chemical and a hepatocarcinogen in rats, induces aryl sulfotransferase-mediated liver DNA and RNA base modifications [Sodum, R. S., Sohn, O. S., Nie, G., and Fiala, E. S. (1994) Chem. Res. Toxicol. 7, 344-351]. Two of these modifications were previously identified as 8-aminoguanine and 8-oxoguanine. We now report that the base moiety of the so far unidentified third nucleic acid modification, namely RX1 in RNA and DX1 in DNA, is 2-hydrazinohypoxanthine (N2-aminoguanine). 2-Hydrazinoinosine and 2-hydrazinodeoxyinosine, synthesized by adapting published procedures, cochromatographed with RX1 and DX1 of liver RNA and DNA, respectively, from 2-nitropropane-treated rats. 2-Hydrazinoinosine and 2-hydrazinodeoxyinosine are unstable in solution like the in vivo products RX1 and DX1. At neutral pH, hypoxanthine nucleoside is the major product of decomposition, while at pH 10 or above, xanthine nucleoside is also formed. RX1 and DX1 could be generated in the anaerobic reactions of hydroxylamine-O-sulfonic acid, an intermediate in the proposed activation pathway of 2-nitropropane, with guanine nucleosides. These results provide further evidence for the activation of 2-nitropropane and other carcinogenic secondary nitroalkanes to a reactive species capable of aminating nucleic acids and proteins.