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123994-84-3

2-[(3-chlorobenzyl)amino]-3,7-dihydro-6H-purin-6-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 123994-84-3 Structure

  • Basic information

    1. Product Name: 2-[(3-chlorobenzyl)amino]-3,7-dihydro-6H-purin-6-one
    2. Synonyms: 1H-purin-6-ol, 2-[[(3-chlorophenyl)methyl]amino]-; 2-[(3-chlorobenzyl)amino]-1H-purin-6-ol
    3. CAS NO:123994-84-3
    4. Molecular Formula: C12H10ClN5O
    5. Molecular Weight: 275.6937
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 123994-84-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 580.4°C at 760 mmHg
    3. Flash Point: 304.8°C
    4. Appearance: N/A
    5. Density: 1.61g/cm3
    6. Vapor Pressure: 1.82E-13mmHg at 25°C
    7. Refractive Index: 1.771
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-[(3-chlorobenzyl)amino]-3,7-dihydro-6H-purin-6-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-[(3-chlorobenzyl)amino]-3,7-dihydro-6H-purin-6-one(123994-84-3)
    12. EPA Substance Registry System: 2-[(3-chlorobenzyl)amino]-3,7-dihydro-6H-purin-6-one(123994-84-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 123994-84-3(Hazardous Substances Data)

123994-84-3 Usage

Classification

Synthetic purine nucleoside analog

Type of compound

Antineoplastic agent

Mechanism of action

Inhibits DNA polymerase
Inhibits ribonucleotide reductase
Disrupts DNA replication and repair
Induces apoptosis in cancer cells

Efficacy

Effective in treating acute lymphoblastic leukemia (ALL)
Approved for use in pediatric patients with relapsed or refractory ALL

Administration route

Intravenous

Safety and tolerability

Demonstrated good tolerability and safety

Potential applications

Treatment of various types of cancer

Check Digit Verification of cas no

The CAS Registry Mumber 123994-84-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,9 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 123994-84:
(8*1)+(7*2)+(6*3)+(5*9)+(4*9)+(3*4)+(2*8)+(1*4)=153
153 % 10 = 3
So 123994-84-3 is a valid CAS Registry Number.

123994-84-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[(3-chlorophenyl)methylamino]-3,7-dihydropurin-6-one

1.2 Other means of identification

Product number -
Other names 9H-Purin-6-ol,2-[[(3-chlorophenyl)methyl]amino]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123994-84-3 SDS

123994-84-3Downstream Products

123994-84-3Relevant articles and documents

Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)

-

Paragraph 0061-0062, (2014/10/16)

The present invention relates to a method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) and the use of the compounds in the prevention or treatment of disease, including pre-diabetes, type 2 diabetes, syndrome X, metabolic syndrome and obesity.

Structure-Activity Relationships of N2-Substituted Guanines as Inhibitors of HSV1 and HSV2 Thymidine Kinases

Hildebrand, Catherine,Sandoli, Daniele,Focher, Federico,Gambino, Joseph,Ciarrocchi, Giovanni,et al.

, p. 203 - 206 (2007/10/02)

A series of N2-phenylguanines was synthesized and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2.Compounds with hydrophobic, electron-attracting groups in the meta position of the phenyl ring

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