13368-14-4

Basic information

• Product Name: 2-Chloro-6-hydroxypurine
• Synonyms: 2-CHLOROHYPOXANTHINE;2-Chloro-6-hydroxypurine;2-Chloro-3,7-dihydro-6H-purin-6-one;2-chloro-7H-purin-6-ol;2-Chloro-1H-purin-6(7H)-one
• CAS NO: 13368-14-4
• Molecular Formula: C₅H₃ClN₄O
• Molecular Weight: 170.56
• EINECS: 201-215-5
• Product Categories: Purines
• Mol File: 13368-14-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300 °C
• Boiling Point: 525.2°Cat760mmHg
• Flash Point: 271.4°C
• Appearance: /
• Density: 2.09g/cm³
• Vapor Pressure: 0.00356mmHg at 25°C
• Refractive Index: 1.91
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.95±0.20(Predicted)
• CAS DataBase Reference: 2-Chloro-6-hydroxypurine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-hydroxypurine(13368-14-4)
• EPA Substance Registry System: 2-Chloro-6-hydroxypurine(13368-14-4)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 13368-14-4(Hazardous Substances Data)

Usage

Description

2-Chloro-6-hydroxypurine is a chemical compound belonging to the purine family, characterized by the presence of a chlorine atom and a hydroxyl group attached to its heterocyclic aromatic structure. As a derivative of purine, it plays a role in the composition of nucleosides and nucleotides within DNA and RNA, and holds potential in pharmaceuticals and organic synthesis due to its biological significance and possible anti-viral and anti-cancer properties, making it a subject of interest in medical research.

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-hydroxypurine is utilized as a pharmaceutical compound for its potential anti-viral and anti-cancer properties, offering a foundation for the development of new therapeutic agents targeting viral infections and cancer cells.
Used in Organic Synthesis:
In the field of organic chemistry, 2-Chloro-6-hydroxypurine serves as a valuable chemical intermediate, facilitating the synthesis of various complex organic molecules and contributing to the advancement of chemical research and development.

InChI:InChI=1/C5H3ClN4O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1-2H,(H,7,8,9,10,11)

Upstream product

• 5451-40-1 2,6-dichloro-7H-purine 

Downstream Products

• 6969-28-4 2-hydrazino-1,7-dihydro-purin-6-one 
• 123994-84-3 2-(3-chlorobenzylamino)-6-hydroxypurine 
• 74491-88-6 9-β-D-arabinofuranosyl-N2-ethylguanine 
• 38819-10-2 9-β-D-arabinofuranosyl-guanine 
• 34793-14-1 2-amino-9-(tri-O-acetyl-β-D-arabinofuranosyl)-1,9-dihydro-purine-6-thione 
• 60966-26-9 2'-amino-2'-deoxyguanosine 
• 76727-51-0 9-(2-amino-2-deoxy-β-D-ribofuranosyl)-2-chlorohypoxanthine 

Relevant articles and documents

NUCLEOSIDE DERIVATIVE OR SALT THEREOF, POLYNUCLEOTIDE SYNTHESIS REAGENT, METHOD FOR PRODUCING POLYNUCLEOTIDE, POLYNUCLEOTIDE, AND METHOD FOR PRODUCING BINDING NUCLEIC ACID MOLECULE

The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

Process for preparing 2-chloro-1,7-dihydropurin-6-one and a process for its purification

A process for the preparation of 2-chloro-1,7-dihydropurin-6-one which comprises the steps of: a) suspending 2-thioxanthine in concentrated hydrocloric acid, to produce a suspension; and b) contacting the suspension with chlorine, to produce 2-chloro-1,7-dihydropurin-6-one.